Am J Transl Res. 2020 Jul 15;12(7):3489-3500.eCollection 2020.

circ_BICD2 acts as a ceRNA to promote tumor progression and Warburg effect in oral squamous cell carcinoma by sponging miR-107 to enhance HK2

Affiliations

Affiliations

  • 1 Department of Stomatology, Henan Province Hospital of TCM Zhengzhou 450002, Henan, P. R. China.
  • 2 Department of Stomatology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.

Free PMC article

Abstract

Numerous studies have proved that the Warburg effect serves a vital role involved in regulating the progression of malignant tumors. Previous studies confirmed that circRNAs act as a novel biomarker for diagnostic and therapeutic in various tumors. However, the functional role and mechanism of circ_BICD2 for the regulation of tumor growth and metastasis in oral squamous cell carcinoma (OSCC) via mediating the Warburg effect are largely unknown. In this study, we found that circ_BICD2 was upregulated in OSCC tumor tissues and cell lines. Inhibition of circ_BICD2 significantly decreased glycolysis, cell proliferation, migration and invasion of OSCC. Moreover, dual-luciferase reporter assay confirmed that circ_BICD2 directly targeted miR-107, as well as a targeted binding between miR-107 and HK2. Mechanistically, upregulation of miR-107 by circ_BICD2-silenced inhibited tumor growth by downregulating the HK2-mediated Warburg effect in OSCC. In conclusion, our findings suggested that circ_BICD2-deficient exerted anti-tumorigenesis and anti-glycolysis in OSCC by sponging miR-107 to downregulate HK2 expression, which provided a new potential therapeutic biomarker for OSCC clinical treatment.

Keywords: HK2; Oral squamous cell carcinoma; Warburg effect; circ_BICD2; miR-107.

在线客服
在线客服
热线电话
 
0
    0
    我的购物车
    购物车是空的去下单