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DNA体内转染Entranster™-in vivo

货号规格单价数量
18668-11-20.5ml¥2,599.00

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产品介绍

Entranster™-in vivo是英格恩生物公司（Engreen Biosystem Co,Ltd.）最新研发合成的用于动物体内转染的转染试剂。Entranster™-in vivo动物体内转染试剂可将DNA转染到动物体内，在动物体内进行蛋白表达实验。

Entranster™-in vivo试剂不是病毒，改变了病毒转染方法复杂、周期长、不稳定、花费大、安全性等诸多问题。Entranster™-in vivo转染效率高，方法简单，无需病毒包装，直接将DNA送入目的细胞的细胞核中表达。

Entranster™-in vivo，非脂质体，采用纳米技术合成，通过保护和浓缩核酸，避免核酸被体液破坏，并通过物理作用将核酸富集在细胞表面，增强核酸进入细胞组织，从而产生作用。Entranster™-in vivo能耐受体内复杂的环境，不产生免疫反应。

推荐应用范围

专用于动物体内转染，可直接转染DNA到动物体内进行：

● 基因治疗的动物体内研究

● 蛋白功能的动物体内研究

主要特点

最快3天可以得到结果，核酸+转染试剂，注射动物，完成转染。

● 肝、肾、心、肺，血液系统，神经系统，生殖系统，皮肤…成功应用。

● 可方便、快捷更换不同的DNA进行动物试验。

● 方法先进，抛弃病毒，众多实验室应用，稳定可靠。

● 比使用病毒节省90%以上费用，时间缩短到3天！

方法简单

如图1所示，只需要将核酸和转染试剂分别稀释，混合，无需过滤，即可直接注射动物。

 

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  76. Cell Death Dis . 2019 Sep 11;10(9):670. doi: 10.1038/s41419-019-1873-x. Transforming Growth Factor (TGF)-β1-induced miR-133a Inhibits Myofibroblast Differentiation and Pulmonary Fibrosis

  77. Cell Transplant.2019 Aug;28(8):985-1001.doi: 10.1177/0963689719834873.Epub 2019 Mar 6. Sodium/Hydrogen Exchanger 1 Participates in Early Brain Injury after Subarachnoid Hemorrhage both in vivo and in vitro via Promoting Neuronal Apoptosis.

  78. Gene . 2019 Aug 20;710:178-185. doi: 10.1016/j.gene.2019.05.050. Epub 2019 May 31. MicroRNA-9 Enhanced Radiosensitivity and Its Mechanism of DNA Methylation in Non-Small Cell Lung Cancer

  79. Biosci Rep . 2019 Jul 5;39(7):BSR20181613. doi: 10.1042/BSR20181613. Print 2019 Jul 31. PLCE1 Promotes Myocardial Ischemia-Reperfusion Injury in H/R H9c2 Cells and I/R Rats by Promoting Inflammation

  80. Cell Death Dis . 2019 Jun 5;10(6):441. doi: 10.1038/s41419-019-1631-0. Mechanism of Snhg8/miR-384/Hoxa13/FAM3A Axis Regulating Neuronal Apoptosis in Ischemic Mice Model.(IF:5.959).

  81. Osteoarthritis Cartilage . 2019 Jun;27(6):922-931. doi:10.1016/j.joca.2019.01.012.
    Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB（Clock突变体和骨关节炎研究）

  82. Cell Transplant . 2019 May;28(5):585-595. doi: 10.1177/0963689719840353. Epub 2019 Apr 8. Potential Roles of NIX/BNIP3L Pathway in Rat Traumatic Brain Injury

  83. Exp Ther Med. 2019 Apr;17(4):3117-3123.doi: 10.3892/etm.2019.7322.Epub 2019 Feb 26.NL1 expression level in Nrx1β and the excitability of PV interneurons in mice with POCD.术后认知功能障碍小鼠NL1表达水平与小白蛋白的中间神经元兴奋性

  84. J Cell Physiol. 2019 Apr;234(4):3720-3729.doi: 10.1002/jcp.27146. Epub 2018 Oct 14.
    MiR-208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A （mir‐208b通过靶向cdkn1a调节细胞周期并促进骨骼肌细胞增殖）

  85. Cell Signal . 2019 Mar;55:65-72. doi: 10.1016/j.cellsig.2018.12.013. Epub 2019 Jan 2. Tmub1 Negatively Regulates Liver Regeneration via Inhibiting STAT3 Phosphorylation

  86. Mol Med Rep.2019 Jan;19(1):327-337.doi: 10.3892/mmr.2018.9640.Epub 2018 Nov 9. N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats.

  87. Mol Imaging Biol. 2018 Oct;20(5):761-770.doi: 10.1007/s11307-018-1180-4.
    Bioluminescence Imaging for Monitoring miR-200c Expression in Breast Cancer Cells and its Effects on Epithelial-Mesenchymal Transition Progress in Living Animals.（mir-200c在乳腺癌细胞上皮间质转化中作用研究）

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    P2Y 12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2′,3′-dideoxycytidine （卫星胶质细胞中P2Y12受体上调与神经性疼痛研究）

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    Neuroprotection of Botch in experimental intracerebral hemorrhage in rats.(IF: 5.168.)（Botch蛋白对脑内出血大鼠神经保护作用）

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    Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy （长链非编码RNA与乳腺癌治疗）

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    Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy.（siRNA与小鼠肺腺癌骨转移研究）

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    Role of miR-145 in chronic constriction injury in rats.(miR-145在大鼠慢性压迫性损伤中的作用）

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    MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-β1, Smad3, and HDAC4 Signaling.(miR-206通过TGF-β1、Smad3和HDAC4信号调控卫星细胞分化进而减弱大鼠骨骼肌萎缩）

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    BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma（BMPR2-pSMAD1 / 5信号通路调节RUNX2表达，并影响去分化软骨肉瘤的进展）

应用本产品文献

发表的部分文章分器官导读

在线查看文章：https://files.engreen.info/share/detail/f60c7b80-8d95-46d8-5f6b-1bb9212c1197 提取码：v6at

序号 研究方向 实验材料 文章题目 期刊
大脑
1 脑损伤 DNA Rbfox-1 contributes to CaMKIIa expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124 Journal of Cerebral Blood Flow &Metabolism
2 脑损伤 DNA Critical role for Annexin A7 in secondary brain injury mediated

by its phosphorylation after experimental intracerebral hemorrhage in rats

 Neurobiology of Disease
3 大脑海马 DNA Activating Transcription Factor 6 reduces Aβ1–42 and restores memory in Alzheimer’s disease model mice International Journal of Neuroscience
4 脑损伤 DNA CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage Chen et al. Journal of Neuroinflammation
5 脑损伤 DNA Sodium/Hydrogen Exchanger 1 Participates in Early Brain Injury after Subarachnoid

Hemorrhage both in vivo and in vitro via Promoting Neuronal Apoptosis

 Cell Transplantatio
6 脑损伤 DNA Exploration of MST1-Mediated Secondary Brain Injury Induced by Intracerebral Hemorrhage in Rats via Hippo Signaling Pathway Translational Stroke Research
7 脑损伤 DNA RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats Journal of Molecular Neuroscience
8 脑损伤 DNA Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurinmediated NMDAR and NFAT dephosphorylation Scientific Reports
9 脑损伤 DNA Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro J Neurosci Res
10 大脑神经 DNA NL1 expression level in Nrx1β and the excitability of PV interneurons in mice with POCD EXPERIMENTAL AND THERAPEUTIC MEDICINE
11 大脑神经 DNA DNA -“TMEM175 mediates Lysosomal function and participates in neuronal injury induced

by cerebral ischemia-reperfusion

 Molecular Brain
12 大脑神经 DNA Galectin‑9 Promotes Neuronal Restoration via Binding TLR‑4 in a Rat Intracerebral Hemorrhage Model NeuroMolecular Medicine
13 大脑神经 DNA Cerebral cavernous malformation 3 relieves subarachnoid hemorrhage-induced neuroinflammation in rats through inhibiting NF-kB signaling pathway Brain Research Bulletin
支气管
1 哮喘 DNA Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis Acta Pharmacologica Sinica
肺
1 非小细胞癌 DNA Targeting LunX inhibits non-small-cell lung cancer growth and metastasis Cancer research
2 急性呼吸窘迫综合征 DNA Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-

Induced Acute Respiratory Distress Syndrome

 Mediators of Inflammation
肝脏
1 肝再生 DNA Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation Cellular Signalling
2 乙肝 DNA Hepatitis B Virus Can Be Inhibited by DNA Methyltransferase 3a

via Specific Zinc_Finger_Induced Methylation of the X Promoter

 BIOCHEMISTRY
胰腺
1 胰岛素

（糖尿病）

 DNA Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation The FASEB Journal
肠
1 肠炎 DNA Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation Acta Pharmaceutica Sinica B
2 肠缺血 mtDNA mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion Cell Death and Disease
骨
1 骨质疏松 DNA Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and

apoptosis of osteoblasts in ovariectomized rats

 Bioscience Reports
2 骨关节炎 DNA Clock Mutant Promotes Osteoarthritis by Inhibiting the Acetylation of NFKB Osteoarthritis and Cartilage
肌肉
1 骨骼肌 DNA Circular RNA circMYBPC1 promotes skeletal muscle differentiation by targeting MyHC Molecular Therapy: Nucleic Acids
免疫
1 慢性荨麻疹 DNA SELE Downregulation Suppresses Mast Cell Accumulation to Protect against Inflammatory Response in Chronic Idiopathic Urticaria Int Arch Allergy Immunol
2 Th17细胞 DNA The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists Theranostics

产品说明书

点此去下载

  1. Entranster™系列转染试剂的成分和原理，化学结构，粒径，电位等数据

  2. siRNA转染与DNA转染有什么不一样?

  3. 体内转染常见问题

  4. 体内转染和病毒感染的比较

  5. 转基因动物/基因敲除动物与体内转染的比较

  6. 小鼠尾静脉注射技巧

相关问题

运输与储存

常温运输，于4℃长期存储，有效期12个月。

安全性

本品使用安全，未发现任何生物、化学毒性。如不慎沾染，用清水冲洗即可。

质量保证

北京英格恩生物科技有限公司对本产品实行严格质量检验，并进行转染验证，以确保产品质量。请用户使用前务必认真阅读操作手册。如用户仍然有问题，请立即联系本公司人员，英格恩公司将负责提供全程技术服务。

使用限制

本品仅限科研用途。

常见问题

DNA 体内转染 in vivo 适合转染什么?

专用于将 DNA 转染到动物体内进行蛋白表达,适用于基因治疗、蛋白功能及基因干预的动物体内研究。

DNA 体内转染 in vivo 怎么给药?用量比例是多少?

将核酸与试剂按 DNA:试剂=1:2 混合后可直接注射;除尾静脉全身递送外,说明书还支持脑室、腹膜、睾丸、皮下肿瘤、肺/气管灌注等局部注射途径,产品页附有小鼠尾静脉注射技巧。

DNA 体内转染 in vivo 有哪些优势?安全吗?

非病毒、非脂质体,采用纳米技术合成,对动物无明显炎性反应;本品使用安全,未发现任何生物、化学毒性,如不慎沾染用清水冲洗即可。

DNA 体内转染 in vivo 操作复杂吗?多久出结果?

不复杂,只需将核酸与试剂分别稀释后混合注射,无需病毒包装;注射后一般 12-48 小时即可检测目的基因表达。

DNA 体内转染 in vivo 如何储存?规格是什么?

常温运输,4℃ 长期存储,有效期 12 个月;规格为 0.5ml(货号 18668-11-2),仅限科研用途。

DNA 体内转染和 RNA 体内转染怎么选?

英格恩体内转染试剂按核酸选:体内递送质粒 DNA 做蛋白表达用 DNA 体内转染;体内递送 siRNA、miRNA 等小 RNA 做基因沉默用 RNA 体内转染;通用 in vivo 适用于小 RNA 的体内递送。

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