J Neuroimmunol . 2014 Jan 15;266(1-2):56-63. doi: 10.1016/j.jneuroim.2013.09.019. Epub 2013 Oct 8.

MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis

Jing Zhang  1 Ye Cheng  1 Wei Cui  1 Meixi Li  1 Bin Li  1 Li Guo  2

Affiliations

  • 1 The Department of Neurology of the Second Hospital of Hebei Medical University, China.
  • 2 The Department of Neurology of the Second Hospital of Hebei Medical University, China. Electronic address: docshuangq@126.com.

Abstract

Mammalian noncoding microRNAs (miRNAs) are suggested to be involved in immune system function. We found that miR-155 expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). Knockdown of miR-155 resulted in low Th1 and Th17 cells and mild EAE, and its overexpression led to more Th1 and Th17 cells and severe EAE. MiR-155 promoted the development of inflammatory Th17/Th1 cell subsets. These findings demonstrate that miR-155 confers susceptibility to EAE by affecting inflammatory T cell responses and can be a new target for therapy of multiple sclerosis.

Keywords: Experimental autoimmune encephalomyelitis; MicroRNAs; Multiple sclerosis; Th1 cells; Th17 cells.

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