Ecotoxicol Environ Saf. 2022 Sep 7;244:114057.doi: 10.1016/j.ecoenv.2022.114057. Online ahead of print. (IF7.129)

Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota

Jiexin Zhang  1 Caiwen Ou  2 Minsheng Chen  3

Affiliations

Abstract

Background: Studies have shown that cadmium (Cd) exposure primarily occurs through diet, and Cd ingestion is a risk factor for atherosclerosis (AS). However, the underlying mechanism remains unclear. As a target organ, the gastrointestinal tract may play a key role in Cd-induced AS. Additionally, as curcumin is insoluble in water but stable in the stomach of acidic pH, it may play regulative roles in the gut.

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