Nat Biotechnol. 2025 Apr 21.doi: 10.1038/s41587-025-02641-9. Online ahead of print. QBEmax is a sequence-permuted and internally protected base editor QBEmax是一个序列置换和内部保护的碱基编辑器 (IF:33.1).
Psychopharmacology (Berl). 2025 Apr 16.doi: 10.1007/s00213-025-06763-5. MiR-223-3p inhibits hippocampal neurons injury and exerts anti- anxiety/depression-like behaviors by directly targeting NLRP3 MiR-223-3p通过直接靶向NLRP3抑制海马神经元损伤并发挥抗焦虑/抑郁样行为
J Stroke Cerebrovasc Dis. 2025 Apr 14;34(7):108317. Circ_0000215 aggravates cerebral ischemic vertigo by targeting miR-361-3p to promote neuroinflammation and apoptosis Circ_0000215通过靶向miR-361-3p促进神经炎症和细胞凋亡来加重缺血性眩晕
Biol Direct. 2025 Apr 9;20(1):48.doi: 10.1186/s13062-025-00643-w. ELK4 induced upregulation of HOMER3 promotes the proliferation and metastasis in glioma via Wnt/β-catenin/EMT signaling pathway ELK4诱导的HOMER3上调通过Wnt/β-catenin/EMT信号通路促进胶质瘤的增殖和转移
Acta Pharmacol Sin . 2025 Apr 3.doi: 10.1038/s41401-025-01534-6. Online ahead of print. The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1 PIWI相互作用RNA CRAPIR通过与SRSF1结合减少p53介导的凋亡来减轻心肌缺血再灌注损伤 (IF:6.900).
Mol Cell Biochem. 2025 Apr 2.doi: 10.1007/s11010-025-05260-9. Human dental follicle cell-derived conditioned media enhance periodontal regeneration by regulating the osteogenic differentiation and inflammation of periodontal ligament stem cells and macrophage polarization 通过调节牙周膜干细胞的成骨分化和炎症以及巨噬细胞极化来促进牙周再生
PLoS Biol. 2025 Apr 1;23(4):e3003047.doi: 10.1371/journal.pbio.3003047. eCollection 2025 Apr. Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice Mdga2缺乏导致BDNF/TrkB信号的异常激活，这是小鼠自闭症相关突触和行为变化的基础(IF:9.8).
Cell Death Discov. 2025 Apr 4;11(1):139.doi: 10.1038/s41420-025-02421-z. Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer CAV1在胰腺癌症生酮饮食和脱铁症中作用的综合研究 (IF:6.1).
Bull Entomol Res. 2025 Mar 24:1-14.doi: 10.1017/S000748532500015X. BmWARS inhibits BmNPV infection via the PI3K-Akt pathway BmWARS通过PI3K-Akt途径抑制BmNPV感染
Sci Rep. 2025 Mar 18;15(1):9225.doi: 10.1038/s41598-025-93081-7. ITGB5 is a prognostic factor in colorectal cancer and promotes cancer progression and metastasis through the Wnt signaling pathway ITGB5是结直肠癌癌症的预后因素，通过Wnt信号通路促进癌症的进展和转移
