Nat Commun. 2026 Apr 20.doi: 10.1038/s41467-026-72181-6. Photoactivatable CRISPR/Cas13d via upconversion nanoparticles for deep tissue RNA engineering and orthopedic therapy 通过上转换纳米颗粒实现光激活CRISPR/Cas13d，用于深层组织RNA工程和骨科治疗(IF:15.7).
Transl Psychiatry. 2026 Apr 4.doi: 10.1038/s41398-026-04014-5. ECM remodeling in the mPFC exacerbates cocaine-induced hyperactivity and impairs threat vigilance 内侧前额叶皮层（mPFC）中的内皮素转化酶（ECM）重塑会加剧可卡因诱导的多动行为，并损害对威胁的警觉性 (IF:6.2).
Cell Calcium. 2026 Apr 19:135:103137.doi: 10.1016/j.ceca.2026.103137. TRPC1 channel modulates mechanical stretch-induced bone marrow mesenchymal stem cell proliferation through Ca2+-dependent ERK1/2 activation TRPC1通道通过Ca2+依赖的ERK1/2激活调节机械拉伸诱导的骨髓间充质干细胞增殖
Biochem Pharmacol. 2026 Apr:246:117723.doi: 10.1016/j.bcp.2026.117723. Epub 2026 Jan 20. Small nucleolar RNA host gene 3 regulates sepsis-induced acute lung injury and inflammation by targeting microRNA-186-5p (IF:5.6).小核仁RNA宿主基因3通过靶向microRNA-186-5p来调节败血症诱导的急性肺损伤和炎症
Sci Rep. 2026 Apr 9.doi: 10.1038/s41598-026-46857-4. CD204 regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following intracerebral hemorrhage CD204调节小胶质细胞/巨噬细胞M1/M2极化，并缓解脑出血后的神经炎症
Int J Radiat Oncol Biol Phys. 2026 Apr 5:S0360-3016(26)00521-3.doi: 10.1016/j.ijrobp.2026.03.037. Alternative End Joining Dependency Imposed by miR-21-5p Defines Radiation Resistance and a Targetable Vulnerability in Oral Squamous Cell Carcinoma miR-21-5p强加的替代末端连接依赖性定义了口腔鳞状细胞癌的辐射抗性和可靶向的脆弱性 (IF:6.5).
Cell Death Dis. 2026 Mar 30.doi: 10.1038/s41419-026-08666-5. AKR1C3-PKM2-oxidative phosphorylation axis drives prostate cancer radioresistance via UBE2T upregulation AKR1C3–PKM2–氧化磷酸化轴通过上调UBE2T来驱动前列腺癌的放射抗性(IF:9.6).
Pharmaceuticals (Basel). 2026 Mar 27;19(4):540.doi: 10.3390/ph19040540. Identification of Dopamine D2 Receptor as a Direct Target of Salidroside and Tyrosol by Integrated Transcriptomic and Biophysical Approaches 通过转录组学和生物物理学综合方法鉴定多巴胺D2受体为红景天苷和酪醇的直接靶点
Cell Chem Biol. 2026 Mar 20:S2451-9456(26)00071-1.doi: 10.1016/j.chembiol.2026.03.001. Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification 通过加帽修饰，工程化手枪状核酶能以更高的效率选择性地靶向KRAS G12V (IF:7.2).
Genomics. 2026 Mar;118(2):111194.doi: 10.1016/j.ygeno.2026.111194. Epub 2026 Jan 5. The translation landscape revealed the novel micropeptides involved in myogenic differentiation of goat skeletal muscle satellite cells
