小核酸转染试剂Entranster^TM-R4000

Int Immunopharmacol. 2024 Mar 30:130:111685.doi: 10.1016/j.intimp.2024.111685. Epub 2024 Feb 20. Inhibition of CISD1 alleviates mitochondrial dysfunction and ferroptosis in mice with acute lung injury 抑制CISD1减轻急性肺损伤小鼠线粒体功能障碍和脱铁性贫血

Reprod Biol. 2024 Mar 7;24(2):100876.doi: 10.1016/j.repbio.2024.100876. Online ahead of print. Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis Circ_0001495通过miRNA-34c-5p/E2F3轴影响子宫内膜异位症的发展

Reprod Biol. 2024 Mar;24(1):100841.doi: 10.1016/j.repbio.2023.100841. Epub 2023 Dec 19. Knockdown of TXNIP alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts 通过激活自噬调节高糖治疗的滋养层细胞增殖和凋亡来减轻妊娠期糖尿病

J Assist Reprod Genet. 2024 Jan 25.doi: 10.1007/s10815-024-03034-8. Online ahead of print. Differential expression of tsRNAs and miRNAs in embryo culture medium: potential impact on embryo implantation 在胚胎培养基中的差异表达：对胚胎植入的潜在影响

Exp Brain Res. 2024 Jan;242(1):33-45.doi: 10.1007/s00221-023-06682-x. Epub 2023 Nov 6. MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage MicroRNA-124通过抑制蛛网膜下腔出血后的AK4/ATF3发挥神经保护作用

Front Immunol. 2024 Jan 4:14:1272108.doi: 10.3389/fimmu.2023.1272108. eCollection 2023. A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors 微管蛋白ε和δ复合物2（TEDC2）在人类肿瘤中的预后意义和致癌作用的全癌分析

J Nutr Biochem. 2023 Dec 28:126:109559.doi: 10.1016/j.jnutbio.2023.109559. Online ahead of print. Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain 用棕榈酸适度替代鱼油刺激的线粒体融合促进Mfn2通过其GTPase结构域与Cpt1α相互作用的β氧化

Pharm Biol. 2023 Dec;61(1):1-11.doi: 10.1080/13880209.2022.2099430. The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway 葛根有效成分葛根素通过miR-29b-3p/IGF1途径抑制动脉粥样硬化中血管平滑肌的增殖和炎症

Chemosphere. 2023 Dec:345:140428.doi: 10.1016/j.chemosphere.2023.140428. Epub 2023 Oct 17. Organic anion transporting polypeptide 3a1 is a novel influx pump for Perfluorooctane sulfonate in Sertoli cells and contributes to its reproductive toxicity 有机阴离子转运多肽3a1是一种新的全氟辛烷磺酸在支持细胞中的流入泵，并导致其生殖毒性

Exp Ther Med. 2023 Nov 9;27(1):6.doi: 10.3892/etm.2023.12293. eCollection 2024 Jan. MicroRNA‑155‑5p affects regulatory T cell activation and immunosuppressive function by targeting BCL10 in myasthenia gravis MicroRNA-155-5p通过靶向重症肌无力患者的BCL10影响调节性T细胞活化和免疫抑制功能

Cell Oncol (Dordr). 2023 Oct;46(5):1333-1350.doi: 10.1007/s13402-023-00814-9. Epub 2023 Apr 26. Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma 肝细胞癌中环状RNA DHPR的异常表达通过调节RASGEF1B/RAS/MAPK轴促进肿瘤生长和转移

Pulm Pharmacol Ther. 2023 Oct:82:102244.doi: 10.1016/j.pupt.2023.102244. Epub 2023 Jul 25. SIRT3 alleviates sepsis-induced acute lung injury by inhibiting pyroptosis via regulating the deacetylation of FoxO3a SIRT3通过调节FoxO3a的脱乙酰作用抑制pyroptosis减轻败血症诱导的急性肺损伤

Oncol Lett. 2023 Aug 17;26(4):427.doi: 10.3892/ol.2023.14013. eCollection 2023 Oct. The 3’‑untranslated region of XB130 regulates its mRNA stability and translational efficiency in non‑small cell lung cancer cells XB130的3’非翻译区调节其在非小细胞肺癌癌症细胞中的mRNA稳定性和翻译效率

Adv Sci (Weinh). 2023 Jun;10(16):e2207089.doi: 10.1002/advs.202207089. Epub 2023 Mar 31. 3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis 诱导H型血管形成和破骨细胞生成的三维仿生钙化软骨细胞

Discov Oncol. 2023 Jun 14;14(1):100.doi: 10.1007/s12672-023-00705-3.MOB kinase activator 1A acts as an oncogene by targeting PI3K/AKT/mTOR in ovarian cancer MOB激酶激活剂1A通过靶向PI3K/AKT/mTOR在卵巢癌症中发挥癌基因作用

Biomed Pharmacother. 2023 May:161:114513.doi: 10.1016/j.biopha.2023.114513. Epub 2023 Mar 15. A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma 一种新的IRES介导的截短Cx32亚型抑制全局mRNA翻译以抑制胶质母细胞瘤 (IF:7.500).

Viruses. 2023 Apr 29;15(5):1099.doi: 10.3390/v15051099. A Novel Targeted RIG-I Receptor 5’Triphosphate Double Strain RNA-Based Adjuvant Significantly Improves the Immunogenicity of the SARS-CoV-2 Delta-Omicron Chimeric RBD-Dimer Recombinant Protein Vaccine 一种新的靶向RIG-I受体5′-三磷酸双链RNA佐剂显著提高严重急性呼吸系统综合征冠状病毒2型德尔塔奥密克戎的免疫原性

Cardiovasc Toxicol. 2023 Apr;23(3-4):147-160.doi: 10.1007/s12012-023-09788-4. Epub 2023 Mar 25.Nogo-A Mediated Endoplasmic Reticulum Stress During Myocardial Ischemic-Reperfusion Injury in Diabetic Rats 糖尿病大鼠心肌缺血再灌注损伤过程中Nogo-A介导的内质网应激

Oncol Lett. 2023 Apr 12;25(6):215.doi: 10.3892/ol.2023.13801. eCollection 2023 Jun. HnRNPAB is an independent prognostic factor in non‑small cell lung cancer and is involved in cell proliferation and metastasis HnRNPAB是非小细胞肺癌癌症的独立预后因子，参与细胞增殖和转移

Oxid Med Cell Longev. 2023 Jan 5:2023:9554457.doi: 10.1155/2023/9554457. eCollection 2023. Lycium barbarum Polysaccharides Regulating miR-181/Bcl-2 Decreased Autophagy of Retinal Pigment Epithelium with Oxidative Stress 枸杞多糖调节miR-181/Bcl-2降低氧化应激下视网膜色素上皮的自噬

Biochem Biophys Res Commun. 2023 Jan 8:639:36-45.doi: 10.1016/j.bbrc.2022.11.067. Epub 2022 Nov 24. Silencing long non-coding RNA SNHG3 repairs the dysfunction of pulmonary microvascular endothelial barrier by regulating miR-186-5p/Wnt axis 沉默长非编码RNA SNHG3通过调节miR-186-5p/Wnt轴修复肺微血管内皮屏障功能障碍

Int J Mol Sci. 2022 Dec 24;24(1):320.doi: 10.3390/ijms24010320. Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes 水杨酸钠通过直接抑制TNF-α刺激的脂肪细胞中磷酸二酯酶3B抑制单核细胞趋化蛋白-1的产生

Int Immunopharmacol. 2022 Dec;113(Pt A):109291.doi: 10.1016/j.intimp.2022.109291. Epub 2022 Oct 14. Bovine-derived α-lactalbumin exhibits cardiovascular protection against aging by ameliorating the inflammatory process in mice 牛源性α-乳清蛋白通过改善小鼠的炎症过程，对衰老具有心血管保护作用

Biochim Biophys Acta Gene Regul Mech. 2022 Oct;1865(7):194874.doi: 10.1016/j.bbagrm.2022.194874. Epub 2022 Sep 16. Dietary choline prevents high fat-induced disorder of hepatic cholesterol metabolism through SREBP-2/HNF-4α/CYP7A1 pathway in a freshwater teleost yellow catfish Pelteobagrus fulvidraco 饲料胆碱通过SREBP-2/HNF-4α/CYP7A1途径预防高脂肪诱导的淡水硬骨鱼黄颡鱼肝脏胆固醇代谢紊乱

Open Life Sci. 2022 Oct 12;17(1):1324-1332.doi: 10.1515/biol-2022-0491. eCollection 2022. S1P promotes corneal trigeminal neuron differentiation and corneal nerve repair via upregulating nerve growth factor expression in a mouse model S1P通过上调小鼠模型中神经生长因子的表达促进角膜三叉神经分化和角膜神经修复

Vet Sci. 2022 Sep 28;9(10):531.doi: 10.3390/vetsci9100531. Effect and Mechanism of siRNAs Targeting IL-1β/TNF-α Combined with BMSCs Transplantation in Ameliorating Rheumatoid Arthritis in Rats 靶向IL-1β/TNF-α的siRNA联合骨髓基质干细胞移植治疗大鼠类风湿性关节炎的作用及机制

Animals (Basel). 2022 Sep 11;12(18):2368.doi: 10.3390/ani12182368. chi-miR-99b-3p Regulates the Proliferation of Goat Skeletal Muscle Satellite Cells In Vitro by Targeting Caspase- 3 and NCOR1 chi-miR-99b-3p靶向Caspase-3和NCOR1调节山羊骨骼肌卫星细胞体外增殖

Viruses. 2022 Aug 30;14(9):1919.doi: 10.3390/v14091919. IFIT3 and IFIT5 Play Potential Roles in Innate Immune Response of Porcine Pulmonary Microvascular Endothelial Cells to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus IFIT3和IFIT5在猪肺微血管内皮细胞对高致病性猪生殖系统的先天免疫反应中发挥潜在作用

Viruses. 2022 Aug 24;14(9):1854.doi: 10.3390/v14091854. A Novel Single-Stranded RNA-Based Adjuvant Improves the Immunogenicity of the SARS-CoV-2 Recombinant Protein Vaccine 一种新型单链RNA佐剂提高严重急性呼吸系统综合征冠状病毒2型重组蛋白疫苗的免疫原性

Cell Cycle. 2022 Aug;21(15):1557-1577.doi: 10.1080/15384101.2022.2057633. Epub 2022 Apr 9. Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184 环状RNA 通过吸收miR-184抑制肝细胞癌（HCC）的进展

Immunopharmacol Immunotoxicol. 2022 Jun 23;1-13.doi: 10.1080/08923973.2022.2078727. Online ahead of print. (IF2.73) LncRNA DLEU2 silencing impedes the migration, invasion and EMT in gastric cancer cell by suppressing PI3K/AKT signaling pathway LncRNA 沉默通过抑制PI3K/AKT信号通路阻止胃癌细胞的迁移、侵袭和EMT

Am J Transl Res. 2022 Jun 15;14(6):4295-4309.eCollection 2022. PKC inhibitors regulate stem cell self-renewal by regulating H3K27me3 and H3K9me3抑制剂通过调节H3K27me3和H3K9me3调节干细胞自我更新

J Cardiovasc Transl Res. 2022 Jun;15(3):500-513.doi: 10.1007/s12265-022-10266-5. Epub 2022 May 2. The Peripheral Circulating Exosomal microRNAs Related to Central Inflammation in Chronic Heart Failure 与慢性心力衰竭中枢炎症相关的外周循环外泌体微小RNA

Dev Comp Immunol. 2022 Jun:131:104382.doi: 10.1016/j.dci.2022.104382. Epub 2022 Mar 1. A cypovirus encoded microRNA negatively regulates the NF-κB pathway to enhance viral multiplication in Silkworm, Bombyx mori 一种密码病毒编码的微小RNA负调控NF-κB通路以增强家蚕的病毒增殖

Mol Biotechnol. 2022 Jun;64(6):660-669.doi: 10.1007/s12033-022-00452-w. Epub 2022 Jan 22. Clinical Potential of lncRNA PPP1R26-AS1 in Breast Cancer and Its Contribution to Cancer Progression lncRNA PPP1R26-AS1在癌症中的临床潜力及其对癌症进展的贡献

Bioengineered. 2022 May;13(5):11503-11516.doi: 10.1080/21655979.2022.2068737. (IF3.269) TNF-like weak inducer of apoptosis / nuclear factor κB axis feedback loop promotes spinal cord injury by inducing astrocyte activation 通过诱导星形胶质细胞活化促进脊髓损伤

Front Immunol. 2022 May 24;13:885896.doi: 10.3389/fimmu.2022.885896. eCollection 2022.(IF7.561) Circular RNA circNUP214 Modulates the T Helper 17 Cell Response in Patients With Rheumatoid Arthritis 环状RNA circNUP214调节类风湿性关节炎患者的T辅助细胞反应

Nucleic Acids Res. 2022 May 6;50(8):e46.doi: 10.1093/nar/gkac014. A Cas6-based RNA tracking platform functioning in a fluorescence-activation mode 基于Cas6的RNA跟踪平台在荧光激活模式下运行

Contrast Media Mol Imaging. 2022 Aug 13:2022:1681864.doi: 10.1155/2022/1681864. eCollection 2022. lncRNA SNHG12 Inhibition Based on Microsystem Cell Imaging Technology Protects the Endothelium from LPS-Induced Inflammation by Inhibiting the Expression of miR-140-3p Target Gene fndc5 基于微系统细胞成像技术的lncRNA SNHG12抑制作用通过抑制miR-140-3p靶基因fndc5的表达保护内皮免受LPS诱导的炎症

Cell Cycle. 2022 Apr 9;1-21. doi: 10.1080/15384101.2022.2057633. Online ahead of print. Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184

Life Sci.2022 Mar 3;120458.doi: 10.1016/j.lfs.2022.120458.dentification of the upstream regulators of KDM5B in gastric cancer

Arch Virol. 2022 Feb 24.doi: 10.1007/s00705-022-05397-8.Identification of endoplasmic-reticulum-associated proteins involved in Bombyx mori nucleopolyhedrovirus entry by RNA-seq analysis

Mol Biotechnol.2022 Jan 22.doi: 10.1007/s12033-022-00452-w.l Potential of lncRNA PPP1R26-AS1 in Breast Cancer and Its Contribution to Cancer Progression

Life Sci 2022 Mar 3;298:120458. doi: 10.1016/j.lfs.2022.120458. Online ahead of print. Identification of the upstream regulators of KDM5B in gastric cancer

Dev Comp Immunol. 2022 Jun;131:104382. doi: 10.1016/j.dci.2022.104382. Epub 2022 Mar 1. A cypovirus encoded microRNA negatively regulates the NF-κB pathway to enhance viral multiplication in Silkworm, Bombyx mori

J Nutr Biochem. 2022 Feb:100:108883.doi: 10.1016/j.jnutbio.2021.108883. Epub 2021 Oct 12. Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways 铜通过氧化应激介导的自噬和Nrf2/PPARγ途径诱导脂质代谢的变化

Mol Biotechnol. 2022 Jan 22. doi: 10.1007/s12033-022-00452-w. Online ahead of print. Clinical Potential of lncRNA PPP1R26-AS1 in Breast Cancer and Its Contribution to Cancer Progression

Aging (Albany NY). 2021 Dec 30;13(24):26095-26117. doi: 10.18632/aging.203799. Epub 2021 Dec 30. endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors

Aging (Albany NY). 2021 Dec 30;13(24):26095-26117.doi: 10.18632/aging.203799. Epub 2021 Dec 30.Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors 敲低hsa_cir_0063526通过调节miR-141-5p/EMT轴和下调雌激素受体抑制子宫内膜异位症进展 (IF: 5.6817).

Front Genet. 2021 Oct 18;12:738559. doi: 10.3389/fgene.2021.738559. eCollection 2021. MiR-320d Inhibits Progression of EGFR-Positive Colorectal Cancer by Targeting TUSC3

Cancer Gene Ther. 2021 Jun;28(6):667-678.doi:10.1038/s41417-020-00247-8. Epub 2020 Oct 27. circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB2促进肾细胞癌的发展

Exp Ther Med.2021 Nov;22(5):1321.doi: 10.3892/etm.2021.10756.Epub 2021 Sep 20.Gas6/Axl signaling pathway promotes proliferation, migration and invasion and inhibits apoptosis in A549 cells. Gas6/Axl信号通路促进A549细胞增殖、迁移和侵袭并抑制凋亡

Exp Ther Med.2021 Nov;22(5):1311.doi: 10.3892/etm.2021.10746. Epub 2021 Sep 16.Blocking tumor necrosis factor-α delays progression of chronic obstructive pulmonary disease in rats through inhibiting MAPK signaling pathway and activating SOCS3/TRAF1

Dig Dis Sci. 2021 Sep;66(9):3036-3044.doi:10.1007/s10620-020-06640-5. Epub 2020 Oct 22.Knockdown of Bcl-2-Associated Athanogene-3 Can Enhance the Efficacy of BGJ398 via Suppressing Migration and Inducing Apoptosis in Gastric Cancer 胃癌

Dis Markers. 2021 Sep 3;2021:5594659.doi: 10.1155/2021/5594659. eCollection 2021.Differential Expression of Long Noncoding RNAs Reveals a Potential Biomarker for Intractable Pemphigus难治性天疱疮的潜在生物标志物

J Invertebr Pathol. 2021Sep;184:107647.doi:10.1016/j.jip.2021.107647. Epub 2021 Jul 23.Bombyx mori Apolipophorin-III inhibits Beauveria bassiana directly and through regulating expression of genes relevant to immune signaling pathways家蚕载脂蛋白III通过调节免疫信号通路相关基因的表达直接抑制白僵菌

Front Physiol. 2021 Aug 4;12:663482. doi: 10.3389/fphys.2021.663482. eCollection 2021. Two Putative Cypovirus-Encoded miRNAs Co-regulate the Host Gene of GTP-Binding Nuclear Protein Ran and Facilitate Virus Replication

J Cell Mol Med. 2020 Jul;24(14):8078-8090.doi:10.1111/jcmm.15439. Epub 2020 Jun 10. New mechanism of nerve injury in Alzheimer’s disease: β-amyloid-induced neuronal pyroptosis阿尔茨海默病神经损伤的新机制：神经元下垂

Oncol Rep. 2021 Jun;45(6):95.doi: 10.3892/or.2021.8046. Epub 2021 Apr 13. Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway黄体酮抑制卵巢癌的进展通过提高结肠癌细胞活性

Front Immunol. 2020 Jun 11;11:1195.doi:10.3389/fimmu.2020.01195. eCollection 2020. Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto’s Thyroiditis在桥本氏病的发病机制中

Brain Behav. 2020 Jun;10(6):e01627.doi: 10.1002/brb3.1627. Epub 2020 Apr 19.Mechanism of microRNA-22 in regulating neuroinflammation in Alzheimer’s disease阿尔茨海默病大鼠神经炎症

Oncol Rep. 2021 Jun;45(6):95.doi: 10.3892/or.2021.8046. Epub 2021 Apr 13. Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway 孕酮通过增加GADD45α/JNK/c-Jun信号通路的活性抑制结肠癌的进展

J Transl Med. 2021 May 26;19(1):223.doi:10.1186/s12967-021-02893-4. miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis自身免疫性脑脊髓炎

Front Immunol. 2021 May 19;12:668760.doi:10.3389/fimmu.2021.668760. eCollection 2021. Resolvin D1 Improves the Treg/Th17 Imbalance in Systemic Lupus Erythematosus Through miR-30e-5p系统性狼疮失衡

Vet Microbiol. 2020 Mar;242:108610.doi:10.1016/j.vetmic.2020.108610. Epub 2020 Feb 10.Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infectionmicroRNA-155在鸡胚成纤维细胞中的调控机制

Front Immunol. 2021 Mar 18;12:626310.doi:10.3389/fimmu.2021.626310. eCollection 2021. Adiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis加剧胶原诱导的炎症反应

J Extracell Vesicles. 2021Feb;10(4):e12068.doi:10.1002/jev2.12068. Epub 2021 Feb 18.Small extracellular vesicles deliver osteolytic effectors and mediate cancer-induced osteolysis in bone metastatic niche

Mol Med Rep. 2021 Feb;23(2):154.doi: 10.3892/mmr.2020.11793. Epub 2020 Dec 23. MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways MicroRNA-223诱导的FBXW7基因抑制通过Notch和Akt/mTOR途径影响结直肠癌癌症细胞的增殖和凋亡

Am J Transl Res. 2021 Feb 15;13(2):672-683.eCollection 2021. POU2F1 induces the immune escape in lung cancer by up-regulating PD-L1上调PD-L1导致肺癌

Mol Med Rep. 2021 Feb;23(2):154.doi: 10.3892/mmr.2020.11793. Epub 2020 Dec 23. MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways结直肠癌细胞的增殖和凋亡

Front Med (Lausanne). 2021 Feb 19;8:630962.doi:10.3389/fmed.2021.630962. eCollection 2021. Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways牙髓细胞对高糖的抵抗作用

Curr Microbiol. 2021 Feb;78(2):490-501.doi: 10.1007/s00284-020-02309-4. Epub 2021 Jan 2. 18 Additional Amino Acids of the Signal Peptide of the Bombyx mori Nucleopolyhedrovirus GP64 Activates Immunoglobulin Binding Protein (BiP) Expression by RNA-seq Analysis 家蚕核型多角体病毒GP64信号肽的18个附加氨基酸激活免疫球蛋白结合蛋白（BiP）的表达

Theranostics.2021 Jan 1;11(2):893-905.doi: 10.7150/thno.48080. eCollection 2021.uman umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis人脐带间干细胞治疗通过MiR-199a-5p/Sirt1/p53轴促进CD4+T细胞衰老改善狼疮(IF:11.556).

Theranostics. 2021 Jan 1;11(2):893-905.doi: 10.7150/thno.48080. eCollection 2021. Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis 人脐带间充质干细胞治疗通过MiR-199a-5p/Sirt1/p53轴增加CD4+T细胞衰老改善狼疮

Life Sci. 2021 Jan 1:264:118687.doi: 10.1016/j.lfs.2020.118687. Epub 2020 Nov 9. PGRN-/- TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration PGRN-/-TAMs来源的外泌体抑制乳腺癌症细胞侵袭迁移及其机制探讨 (IF:6.100).

Life Sci. 2021 Jan 1;264:118687.doi: 10.1016/j.lfs.2020.118687. Epub 2020 Nov 9.PGRN -/- TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism explorationTAMs衍生的外显体抑制乳腺癌细胞

Toxicol Appl Pharmacol. 2021 Jan 1;410:115336.doi:10.1016/j.taap.2020.115336. Epub 2020 Nov 17.Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism藁本内酯抑制非小细胞肺癌的增殖

Curr Microbiol. 2021 Feb;78(2):490-501. doi: 10.1007/s00284-020-02309-4. Epub 2021 Jan 2. 18 Additional Amino Acids of the Signal Peptide of the Bombyx mori Nucleopolyhedrovirus GP64 Activates Immunoglobulin Binding Protein (BiP) Expression by RNA-seq Ana

Mol Nutr Food Res. 2020 Dec;64(23):e2000383.doi: 10.1002/mnfr.202000383. Epub 2020 Nov 9. Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6 饱和脂肪酸通过调节miR-34a/细胞周期蛋白依赖性激酶6促进肝细胞衰老

J Recept Signal Transduct Res. 2020 Dec;40(6):550-559.doi:10.1080/10799893.2020.1768547. Epub 2020 Jun 1. Antagonizing effect of icaritin on apoptosis and injury of hippocampal neurocytes induced by amyloid beta via GR/BDNF signaling pathway大鼠海马神经细胞损伤的实验研究

Neurochem Res. 2020 Dec;45(12):3045-3058.doi:10.1007/s11064-020-03152-6. Epub 2020 Oct 23. CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke缺血性脑卒中的线粒体生物发生与功能CTRP3

Sci Rep.2020 Oct 27;10(1):18303.doi: 10.1038/s41598-020-75358-1.MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell.

J Cancer.2020 Feb 3;11(8):2222-2233.doi: 10.7150/jca.39679. eCollection 2020.
The Role of MiR-5094 as a Proliferation Suppressor during Cellular Radiation Response via Downregulating STAT5b. MiR-5094作为细胞辐射反应中的增殖抑制因子降低STAT5b的表达.

Oncol Lett. 2020 Oct;20(4):68.doi: 10.3892/ol.2020.11929. Epub 2020 Jul 29. Members of the miR-30 family inhibit the epithelial-to-mesenchymal transition of non-small-cell lung cancer cells by suppressing XB130 expression levels抑制非小细胞肺癌细胞的上皮向间充质转化

Mol Ther.2020 Nov 4;28(11):2442-2457.doi: 10.1016/j.ymthe.2020.09.010.Epub 2020 Sep 6.Lactate Induces Production of the tRNA His Half to Promote B-lymphoblastic Cell Proliferation.乳酸诱导tRNA His半体的产生,促进B淋巴细胞增殖.(IF:11.454).

Immunol Lett. 2020 Sep:225:44-49.doi: 10.1016/j.imlet.2020.06.009. Epub 2020 Jun 15. Yes-associated protein upregulates filopodia formation to promote alveolar epithelial-cell phagocytosis Yes相关蛋白上调丝足形成促进肺泡上皮细胞吞噬

Immunol Lett. 2020 Sep;225:44-49.doi: 10.1016/j.imlet.2020.06.009. Epub 2020 Jun 15. Yes-associated protein upregulates filopodia formation to promote alveolar epithelial-cell phagocytosis肺泡上皮细胞吞噬作用

Mamm Genome.2020 Aug;31(7-8):197-204.doi: 10.1007/s00335-020-09842-4. Epub 2020 Jun 15.ryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer

Brain Behav. 2020 Jun; 10(6): e01627.Published online 2020 Apr 19. doi: 10.1002/brb3.1627Mechanism of microRNA‐22 in regulating neuroinflammation in Alzheimer’s disease. microRNA-22调节阿尔茨海默病神经炎症的机制

Cell Stress Chaperones.2020 May;25(3):395-406.doi: 10.1007/s12192-020-01079-z.Epub 2020 Mar 2.Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation

Glia. 2020 Nov;68(11):2415-2426.doi: 10.1002/glia.23850. Epub 2020 May 27.Activation of astrocytic sigma-1 receptor exerts antidepressant-like effect via facilitating CD38-driven mitochondria transfer星形胶质细胞sigma-1受体的激活

Cell Death Dis.2020 Apr 27;11(4):293.doi: 10.1038/s41419-020-2496-y.CD41-deficient exosomes from non-traumatic femoral head necrosis tissues impair osteogenic differentiation and migration of mesenchymal stem cells.非创伤性股骨头坏死组织中CD41缺陷的外显体影响间充质干细胞的成骨分化和迁移(IF:8.469).

Mol Carcinog.2020 May;59(5):557-568.doi: 10.1002/mc.23180.Epub 2020 Mar 11.XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the proliferation and metastasis of non-small-cell lung cancer cells.由miR-203、miR-219和miR-4782-3p调节的XB130介导非小细胞肺癌细胞的增殖和转移

J Nutr.2020 Mar 1;150(3):464-474.doi:10.1093/jn/nxz282.miR-144 Mediates High Fat-Induced Changes of Cholesterol Metabolism via Direct Regulation of C/EBPα in the Liver and Isolated Hepatocytes of Yellow CatfishmiR-144通过直接调节黄鲶肝脏和离体肝细胞中的C/EBPα介导高脂诱导的胆固醇代谢变化

Biochim Biophys Acta Mol Basis Dis. 2019 Dec 1;1865(12):165540. doi: 10.1016/j.bbadis.2019.165540. Epub 2019 Aug 27.(IF:4.328).
G-MDSC-derived exosomes attenuate collagen-induced arthritis by impairing Th1 and Th17 cell responses.（G-MDSC来源的外体和胶原诱导的关节炎研究）

Cell Cycle.2019 Oct;18(19):2432-2446.doi: 10.1080/15384101.2019.1648956.Epub 2019 Aug 25.lvement of FBP1 in prostate cancer cell epithelial mesenchymal transition, invasion and metastasis by regulating the MAPK signaling pathway

Sci Rep.2019 Nov 22;9(1):17417.doi: 10.1038/s41598-019-53870-3.GF/Flk1 Mechanism is Involved in Roxarsone Promotion of Rat Endothelial Cell Growth and B16F10 Xenograft Tumor Angiogenesis.

Mol Ther Nucleic Acids. 2019 Sep 6;17:38-48. doi: 10.1016/j.omtn.2019.05.004. Epub 2019 May 22.(IF:5.919).
Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto’s Thyroiditis via Sponging miR125a-3p.（桥本甲状腺炎中cirRNA表达研究）

Biosci Rep. 2019 Aug 19;39(8). pii: BSR20190109. doi: 10.1042/BSR20190109. Print 2019 Aug 30.
Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.（利拉鲁肽和人髓核细胞凋亡研究）

J Autoimmun. 2019 Aug;102:96-113. doi: 10.1016/j.jaut.2019.04.018. Epub 2019 May 23.(IF:7.543).
NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3.（mir-34a与Treg/Th17细胞平衡研究）

Cancer Lett. 2019 May 28;450:110-122. doi: 10.1016/j.canlet.2019.02.029. Epub 2019 Feb 18.(IF:6.491).STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.(Stat3抑制可增强CDN诱导的STING信号和抗肿瘤免.）

Chemosphere. 2019 May;223:165-170. doi: 10.1016/j.chemosphere.2019.01.169. Epub 2019 Feb 1.(IF:4.427).
Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway.（多氯代二苯硫醚可通过AHR-CYP1A1途径诱导活性氧和基因毒性.）

Leuk Lymphoma. 2019 Mar;60(3):772-781. doi: 10.1080/10428194.2018.1493727. Epub 2019 Jan 15.
Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma.（多发性骨髓瘤中Hedgehog和NF-κB信号通路之间的相互作用.）

Eur Rev Med Pharmacol Sci.2019 Apr;23(8):3291-3301.doi: 10.26355/eurrev_201904_17691.Increased long noncoding RNA LINC00511 is correlated with poor prognosis and contributes to cell proliferation and metastasis by modulating miR-424 in hepatocellular carcinoma.长链非编码RNA LINC00511与肝细胞癌预后不良相关，并通过调节miR-424促进细胞增殖和转移

Mol Cancer. 2019 Mar 30;18(1):61. doi: 10.1186/s12943-019-0978-2.(IF:27.401).
Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.（LncRNA Pvt1与粒细胞源性骨髓抑制细胞的免疫抑制活性研究）

Int J Mol Med. 2018 Jun;41(6):3379-3393. doi: 10.3892/ijmm.2018.3526. Epub 2018 Mar 1.
MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway.（间充质干细胞成骨细胞分化研究）

Eur Rev Med Pharmacol Sci. 2018 May;22(9):2572-2579.doi: 10.26355/eurrev_201805_14950. Overexpression of PER3 reverses paclitaxel resistance of prostate cancer cells by inhibiting the Notch pathway PER3的过表达通过抑制Notch途径逆转前列腺癌症细胞对紫杉醇的耐药性

J Virol. 2018 Apr 13;92(9). pii: e00033-18. doi: 10.1128/JVI.00033-18. Print 2018 May 1.
Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth.（EB病毒与B淋巴细胞细胞粘附和生长研究）

Mol Med Rep. 2018 Apr;17(4):5851-5859. doi: 10.3892/mmr.2018.8601. Epub 2018 Feb 13.
Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells.（siRNA对高糖和高游离脂肪酸环境下卫星胶纸细胞P2X7受体表达影响研究）

Eur Rev Med Pharmacol Sci. 2018 Mar;22(5):1297-1306.doi: 10.26355/eurrev_201803_14471. LncRNA SNHG12 regulated the proliferation of gastric carcinoma cell BGC-823 by targeting microRNA-199a/b-5p LncRNA-SNGG12靶向微小RNA-199a/b-5p调控胃癌细胞BGC-823增殖

Biofactors. 2018 Mar;44(2):123-136. doi: 10.1002/biof.1395. Epub 2017 Nov 29.
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells.（二氢杨梅素抑制NLRP3炎性体依赖的细胞死亡研究）

Exp Cell Res. 2017 Dec 15;361(2):342-352. doi: 10.1016/j.yexcr.2017.11.002. Epub 2017 Nov 2.
Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.（siRNA转染小鼠胶质瘤细胞与促红细胞生成素对早期脑损伤作用研究）

Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5661-5667.doi: 10.26355/eurrev_201712_14010. High expression of LncRNA CASC15 is a risk factor for gastric cancer prognosis and promote the proliferation of gastric cancer lnc-CRNDE的高表达是急性髓系白血病的生物标志物，并促进急性髓系细胞系U937的恶性进展

J Cell Mol Med. 2017 Apr;21(4):802-815. doi: 10.1111/jcmm.13022. Epub 2016 Nov 25.
A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation.（SASH1引起病理性色素沉着研究）

J Exp Clin Cancer Res. 2016 Sep 17;35(1):145. doi: 10.1186/s13046-016-0423-y.
Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells.（p21基因激活与人类癌细胞中dsRNA的机制和功能）

J Orthop Translat. 2016 Jun 8;7:1-6. doi: 10.1016/j.jot.2016.05.011. eCollection 2016 Oct.
Knockdown of asporin affects transforming growth factor-β1-induced matrix synthesis in human intervertebral annulus cells.（Asporin的敲降可影响人类椎间环细胞中转化生长因子-β1诱导的基质合成）

Immunol Res. 2016 Apr;64(2):489-96. doi: 10.1007/s12026-015-8715-4.
Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome.（LncRNA-TMEVPG1的上调可增强Sjögren综合征患者T辅助细胞1型细胞反应）

Stem Cells Dev. 2016 Mar 15;25(6):477-91. doi: 10.1089/scd.2015.0301. Epub 2016 Feb 22.
High-Efficient Transfection of Human Embryonic Stem Cells by Single-Cell Plating and Starvation.（人类胚胎干细胞）

Mol Med Rep. 2016 Mar;13(3):2492-8. doi: 10.3892/mmr.2016.4814. Epub 2016 Jan 27.
Downregulated microRNA-23b promotes BMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2.（下调的microRNA-23b通过靶向Runx2促进C2C12成肌细胞中BMP9介导的骨生成）

Int J Mol Med. 2015 Dec;36(6):1497-506. doi: 10.3892/ijmm.2015.2363. Epub 2015 Oct 9.
miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells.（miR-21激活小鼠干细胞中BMP9 /Smad信号通路与BMP9 协同作用于成骨细胞分化的研究）

Mol Biosyst. 2015 Nov;11(11):3040-7. doi: 10.1039/c5mb00347d.
The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway.（肝肺综合征相关的研究）

Tumour Biol. 2016 Mar;37(3):3479-88. doi: 10.1007/s13277-015-4086-7. Epub 2015 Oct 9.
MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2.（MiR-30a通过靶向作用于小家畜相关的转录因子2（Runx2）进而调节人骨肉瘤细胞的增值、迁移及侵袭）

Endocrine. 2015 Aug;49(3):752-60. doi: 10.1007/s12020-015-0546-5. Epub 2015 Feb 11.
MiR-346 regulates CD4⁺CXCR5⁺ T cells in the pathogenesis of Graves’ disease.（甲亢研究）

J Immunol. 2015 Aug 1;195(3):1301-11. doi: 10.4049/jimmunol.1500209. Epub 2015 Jun 19.
MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.（MicroRNA-9 通过靶向作用于Runx1调节髓源性抑制细胞的分化和功能）

Immunol Res. 2015 Jun;62(2):129-36. doi: 10.1007/s12026-015-8643-3.
Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto’s thyroiditis.（microRNA-125a-3p的低表达可以上调淋巴瘤性（样）甲状腺肿病人白细胞介素-23受体的水平）.

PLoS One. 2015 Mar 31;10(3):e0121510. doi: 10.1371/journal.pone.0121510. eCollection 2015.
MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.（MicroRNA-22 通过靶向作用于p38蛋白削弱树突状细胞的抗肿瘤能力）

Apoptosis. 2015 Jan;20(1):92-109. doi: 10.1007/s10495-014-1058-0.
RIP1-dependent Bid cleavage mediates TNFα-induced but Caspase-3-independent cell death in L929 fibroblastoma cells.（成纤维细胞瘤细胞研究）

Mol Biosyst. 2014 Apr;10(4):759-66. doi: 10.1039/c3mb70391f. Epub 2014 Jan 23.
Paxillin suppresses the proliferation of HPS rat serum treated PASMCs by up-regulating the expression of cytoskeletal proteins.

Apoptosis. 2013 Nov;18(11):1348-1362. doi: 10.1007/s10495-013-0866-y.
The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.

Int J Nanomedicine . 2013;8:3805-16. doi: 10.2147/IJN.S48950. Epub 2013 Oct 2. Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-α and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line. (IF:6.400).

Cell Signal. 2013 Jun;25(6):1526-38. doi: 10.1016/j.cellsig.2012.12.025. Epub 2013 Jan 16.
SASH1 regulates melanocyte transepithelial migration through a novel Gαs-SASH1-IQGAP1-E-Cadherin dependent pathway.

J Immunol. 2013 Mar 1;190(5):2437-46. doi: 10.4049/jimmunol.1202282. Epub 2013 Jan 25.
Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways.

Respir Physiol Neurobiol. 2013 Jan 15;185(2):332-8. doi: 10.1016/j.resp.2012.09.009. Epub 2012 Oct 8.
Effect of annexin A2 on hepatopulmonary syndrome rat serum-induced proliferation of pulmonary arterial smooth muscle cells.

Genes Immun. 2012 Dec;13(8):621-31. doi: 10.1038/gene.2012.45. Epub 2012 Oct 4.
TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7.

Cytokine. 2012 Nov;60(2):505-13. doi: 10.1016/j.cyto.2012.06.317. Epub 2012 Jul 31.
BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells.

Biochem J. 2012 Nov 1;447(3):407-16. doi: 10.1042/BJ20120256.
Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation.

J Cell Sci. 2012 Sep 15;125(Pt 18):4219-29. doi: 10.1242/jcs.086553. Epub 2012 May 28.
Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability.

J Radiat Res. 2012 Jul;53(4):516-25. doi: 10.1093/jrr/rrs002. Epub 2012 Jun 6.
MicroRNA-148b enhances the radiosensitivity of non-Hodgkin’s Lymphoma cells by promoting radiation-induced apoptosis.

Genes Immun. 2012 Jun;13(4):311-20. doi: 10.1038/gene.2011.87. Epub 2012 Jan 26.
Global mapping of H3K4me3 and H3K27me3 reveals chromatin state-based regulation of human monocyte-derived dendritic cells in different environments.

Cell Biochem Funct. 2012 Mar;30(2):108-13. doi: 10.1002/cbf.1823. Epub 2011 Oct 26.
The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells.

Virus Res. 2012 Jan;163(1):183-9. doi: 10.1016/j.virusres.2011.09.016. Epub 2011 Sep 16.
Small interfering RNA against the 2C genomic region of coxsackievirus B3 exerts potential antiviral effects in permissive HeLa cells.

J Sex Med. 2011 Oct;8(10):2773-80. doi: 10.1111/j.1743-6109.2011.02412.x. Epub 2011 Aug 5.
Up-regulation of VEGF by small activator RNA in human corpus cavernosum smooth muscle cells.

J Immunol. 2011 Apr 15;186(8):4716-24. doi: 10.4049/jimmunol.1002989. Epub 2011 Mar 7.
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.

Microvasc Res. 2010 Jul;80(1):158-65. doi: 10.1016/j.mvr.2010.01.003. Epub 2010 Jan 14.
A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats.

Apoptosis. 2010 Apr;15(4):488-98. doi: 10.1007/s10495-009-0439-2.
A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats.

J Biol Chem. 2010 Apr 2;285(14):10890-901. doi: 10.1074/jbc.M109.058347. Epub 2010 Jan 26.
Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.