RNA体内转染EntransterTM-in vivo

货号规格单价数量
18668-11-10.5ml¥2,399.00

加入购物车

清除

订购金额满1000元,免运费。

产品介绍

EntransterTM-in vivo是英格恩生物公司(Engreen Biosystem Co,Ltd.)最新研发合成的用于动物体内转染的转染试剂。EntransterTM-in vivo动物体内转染试剂可将小片断RNA如siRNA,miRNA,mimic、inhibitor转染到动物体内,在动物体内进行RNA干扰等实验。

EntransterTM-in vivo试剂不是病毒,改变了病毒转染方法复杂、周期长、不稳定、花费大、安全性等诸多问题。EntransterTM-in vivo转染效率高,方法简单,无需病毒包装,直接将RNA送入目的细胞的细胞核中表达。

EntransterTM-in vivo,非脂质体,采用纳米技术合成,通过保护和浓缩核酸,避免核酸被体液破坏,并通过物理作用将核酸富集在细胞表面,增强核酸进入细胞组织,从而产生作用。EntransterTM-in vivo能耐受体内复杂的环境,不产生免疫反应。

推荐应用范围

专用于动物体内转染,可直接转染RNA到动物体内进行:

● 基因治疗的动物体内研究

● RNA干扰的动物体内研究

● 蛋白功能的动物体内研究

 

主要特点

最快3天可以得到结果,核酸+转染试剂,注射动物,完成转染。

● 肝、肾、心、肺,血液系统,神经系统,生殖系统,皮肤…成功应用。

● 可方便、快捷更换不同的小片断RNA进行动物试验。

● 方法先进,抛弃病毒,众多实验室应用,稳定可靠。

● 比使用病毒节省90%以上费用,时间缩短到3天!

方法简单

如图所示,只需要将核酸和转染试剂分别稀释,混合,无需过滤,即可直接注射动物。

转染效果

将EntransterTM-in vivo与Ambion in vivo siRNA(作用于凝血因子VII)和阴性siRNA通过尾静脉注射成年小鼠,2天后,取动物肝脏检测。在mRNA水平和蛋白水平观察干扰效果。见上图,图中最左侧组为对照组注射阴性siRNA为3mg/kg,后边3组为每kg动物注射阳性siRNA量分别为1mg/kg,2mg/kg和3mg/kg情况。

各器官转染

根据推荐用量注射EntransterTM-in vivo和siRNA(作用于Lamin A/C)和阴性siRNA到成年小鼠。注射后2天收集相应的组织,分离RNA,用qRT-PCR分析Lamin A/C基因的表达水平。图4为尾静脉结果,图5为各器官分别局部注射结果。

  1. Acta Pharmacol Sin. 2022 Apr 6. doi: 10.1038/s41401-022-00893-8. Online ahead of print. Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9 (IF:6.150).

  2. Environ Toxicol.2022 Mar;37(3):539-548.doi: 10.1002/tox.23419. Epub 2021 Nov 24. MicroRNA-577 aggravates bone loss and bone remodeling by targeting thyroid stimulating hormone receptor in hyperthyroid-associated osteoporosis

  3. Microvasc Res.2022 May;141:104309.doi: 10.1016/j.mvr.2021.104309. Epub 2022 Jan 4. VEGFR 2 in vascular smooth muscle cells mediates H 2 S-induced dilation of the rat cerebral basilar artery

  4. Cancer Manag Res.2022 Mar 17;14:1165-1177.doi: 10.2147/CMAR.S335749. eCollection 2022.GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK Pathway

  5. Dig Dis Sci.2022 Mar 21.doi:10.1007/s10620-022-07453-4.UBE2W Improves the Experimental Colitis by Inhibiting the NF-κB Signaling Pathway

  6. Eur J Neurosci. 2022 Apr;55(7):1695-1708. doi: 10.1111/ejn.15622. Epub 2022 Mar 28. Sevoflurane protects mice from cerebral ischaemic injury by regulating microRNA-203-3p/HDAC4/Bcl-2 axis

  7. Exp Ther Med. 2022 Feb;23(2):139.doi: 10.3892/etm.2021.11062.Epub 2021 Dec 14. Transplantation of IL-1β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats.

  8. J Endocrinol Invest.2022 Jan;45(1):17-28.doi: 10.1007/s40618-021-01606-4.Epub 2021 Jun 18.mediating the expression of histone demethylase KDM5C.

  9. Brain Res Bull.2022 Jan;178:17-28.doi: 10.1016/j.brainresbull.2021.11.003.Epub 2021 Nov 11. The circadian clock regulator Bmal1 affects traumatic brain injury in rats through the p38 MAPK signalling pathway.(IF:4.077).

  10. Oxid Med Cell Longev.2022 Feb 16;2022:8603427.doi: 10.1155/2022/8603427.eCollection 2022.miR-155-5p in Extracellular Vesicles Derived from Choroid Plexus Epithelial Cells Promotes Autophagy and Inflammation to Aggravate Ischemic Brain Injury in Mice.(IF:6.543).

  11. Biosci Rep.2022 Jan 28;42(1):BSR20210116.doi: 10.1042/BSR20210116.MiR-34a-3p suppresses pulmonary vascular proliferation in acute pulmonary embolism rat by targeting DUSP1.

  12. Bioengineered.2022 Jan;13(1):774-788.doi:10.1080/21655979.2021.2012919.miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury.

  13. Cytokine.2022 Feb 17;152:155823.doi: 10.1016/j.cyto.2022.155823.IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis.

  14. Bioengineered.2022 Jan;13(1):774-788.doi: 10.1080/21655979.2021.2012919.in type I diabetes through triggering mitochondrial injury.

  15. Exp Ther Med. 2022 Feb;23(2):172. doi: 10.3892/etm.2021.11095. Epub 2021 Dec 27. Effect of Src tyrosine kinase on a rat model of asthma

  16. Neural Regen Res.2022 Aug;17(8):1795-1801.doi: 10.4103/1673-5374.332157.Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage.(IF:5.135).

  17. J Biol Chem.2022 Jan 5;298(2):101561.doi:10.1016/j.jbc.2022.101561.Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.(IF:5.157).

  18. Mol Ther.2022 Jan 22;S1525-0016(22)00033-8.doi: 10.1016/j.ymthe.2022.01.033.A microRNA checkpoint for Ca 2+ signaling and overload in acute pancreatitis. (IF:11.454).

  19. Cytokine. 2022 Apr;152:155823. doi: 10.1016/j.cyto.2022.155823. Epub 2022 Feb 17. IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis

  20. Bioengineered. 2022 Feb;13(2):3969-3980. doi: 10.1080/21655979.2022.2031401. Knockdown of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 protects against intracerebral hemorrhage through microRNA-146a-mediated inhibition of inflammation and oxidative stress

  21. iScience. 2022 Feb 21;25(3):103949. doi: 10.1016/j.isci.2022.103949. eCollection 2022 Mar 18. Long noncoding RNA Lnc-DIF inhibits bone formation by sequestering miR-489-3p (IF:6.007).

  22. Osteoarthritis Cartilage 2022 Apr;30(4):613-625. doi: 10.1016/j.joca.2022.01.002. Epub 2022 Jan 7. N(6)-methyladenosine RNA methyltransferase like 3 inhibits extracellular matrix synthesis of endplate chondrocytes by downregulating sex-determining region Y-Box transcription factor 9 expression under tension. (IF:6.576).

  23. Microvasc Res. 2022 May;141:104309. doi: 10.1016/j.mvr.2021.104309. Epub 2022 Jan 4. VEGFR 2 in vascular smooth muscle cells mediates H 2 S-induced dilation of the rat cerebral basilar artery

  24. Int Arch Allergy Immunol. 2021;182(2):83-93.doi: 10.1159/000507289. Epub 2020 Dec 7. SELE Downregulation Suppresses Mast Cell Accumulation to Protect against Inflammatory Response in Chronic Idiopathic Urticaria肥大细胞慢性特发性荨麻疹的反应

  25. Bioengineered. 2021 Dec;12(1):5566-5582.doi:10.1080/21655979.2021.1966258. Long non-coding RNA TUG1 knockdown prevents neurons from death to alleviate acute spinal cord injury via the microRNA-338/BIK axis长时间非编码RNA TUG1敲除通过microRNA-338/BIK轴阻止神经元死亡以减轻急性脊髓损伤

  26. J Nutr Biochem. 2022 Mar;101:108923. doi: 10.1016/j.jnutbio.2021.108923. Epub 2021 Nov 26. Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating “PPAR-γ-glutaminolysis-DEPTOR” pathway in pulmonary fibrosis (IF:6.048).

  27. Brain Res.2021 Oct 9;147685.doi: 10.1016/j.brainres.2021.147685. Online ahead of print.Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury.在大鼠创伤性脑损伤模型中,Miro1通过线粒体转运途径提供神经保护

  28. Neural Regen Res.2021 Dec;16(12):2453-2464.doi: 10.4103/1673-5374.313049.SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses. SOCS1/JAK2/STAT3通过炎症反应调节蛛网膜下腔出血诱导的早期脑损伤(IF:5.135)

  29. Eur J Pharmacol. 2021 Oct 15;909:174401. doi: 10.1016/j.ejphar.2021.174401. Epub 2021 Aug 3. SPTBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21

  30. Mol Neurobiol. 2021 Oct;58(10):4999-5013.doi:10.1007/s12035-021-02468-w. Epub 2021 Jul 7. Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage脑出血大鼠模型的功能障碍(IF:5.590).

  31. Front Vet Sci. 2021 Oct 4;8:700930. doi: 10.3389/fvets.2021.700930. eCollection 2021. Directed Expression of Tracheal Antimicrobial Peptide as a Treatment for Bovine-Associated Staphylococcus Aureus-Indu

  32. Prostate. 2022 Jan;82(1):26-40. doi: 10.1002/pros.24245. Epub 2021 Sep 30. Regulatory mechanism of androgen receptor on NCAPD3 gene expression in prostate cancer

  33. Cell Res.2021 Sep 24.doi: 10.1038/s41422-021-00565-y. Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function (IF:25.617).

  34. Mol Med.2021 Sep 17;27(1):113.doi: 10.1186/s10020-021-00372-6.Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling.环状RNA-0007059通过抑制microRNA-1278/SHP-1/STAT3信号传导,在肾炎细胞模型中保护细胞活力并减少炎症.(IF:6.354).

  35. Aging (Albany NY).2021 Sep 22;13(18):22242-22255.doi: 10.18632/aging.203530.Epub 2021 Sep 22.miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway.miR-21通过p53/Bcl-2/Bax信号通路调节缺血性神经元损伤

  36. Oncol Rep.2021 Sep;46(3):187.doi: 10.3892/or.2021.8138. Epub 2021 Jul 19.Mechanism of tumor‑derived extracellular vesicles in regulating renal cell carcinoma progression by the delivery of MALAT1.肿瘤源性细胞外小泡通过MALAT1调节肾细胞癌发展的机制

  37. PeerJ.2021 Sep 14;9:e12138.doi: 10.7717/peerj.12138.eCollection 2021.Glucosylceramide synthase regulates hepatocyte repair after concanavalin A-induced immune-mediated liver injury. 葡萄糖神经酰胺合成酶调节刀豆蛋白A诱导的免疫介导肝损伤后的肝细胞修复

  38. Mol Med Rep. 2021 Sep;24(3):682.doi:10.3892/mmr.2021.12321. Epub 2021 Jul 28.Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on the autophagy pathway急性肝衰竭(ALF)

  39. Neuropharmacology. 2021 Sep 15;196:108671.doi:10.1016/j.neuropharm.2021.108671. Epub 2021 Jun 18. MicroRNA-23b attenuates tau pathology and inhibits oxidative stress by targeting GnT-III in Alzheimer’s disease过靶向阿尔茨海默病中的GnT III

  40. Inflammopharmacology. 2021 Oct;29(5):1487-1501. doi: 10.1007/s10787-021-00873-0. Epub 2021 Sep 12. The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund’s adjuvant-induced chronic inflammatory pain

  41. Leuk Res. 2021 Sep 20;110:106709.doi: 10.1016/j.leukres.2021.106709. Online ahead of print. Tumor-associated macrophages modulate angiogenesis and tumor growth in a xenograft mouse model of multiple myeloma肿瘤相关巨噬细胞调节多发性骨髓瘤异种移植小鼠模型的血管生成和肿瘤生长

  42. Ther Adv Chronic Dis.2021 Aug 25;12:2040622321995685.doi: 10.1177/2040622321995685.eCollection 2021.Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF/ PTEN/ Wnt/β-catenin axis.褪黑素通过HGF/PTEN/Wnt/β-catenin轴恢复骨质疏松症受损的骨髓间充质干细胞成骨潜能并减轻骨丢失.(IF:5.091).

  43. Invest New Drugs.2021 Aug;39(4):949-960.doi: 10.1007/s10637-021-01073-x.Epub 2021 Feb 3.Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models.

  44. Eur J Pharmacol.2021 Oct 15;909:174401.doi: 10.1016/j.ejphar.2021.174401.Epub 2021 Aug 3.TBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21

  45. Inflammation.2021 Aug;44(4):1581-1591.doi: 10.1007/s10753-021-01443-w.Epub 2021 Mar 2.MiR-23a Is Involved in Myocardial Ischemia/Reperfusion Injury by Directly Targeting CX43 and Regulating Mitophagy.MiR-23a通过直接靶向CX43和调节有丝分裂吞噬作用参与心肌缺血/再灌注损伤过程

  46. Ann Hepatol.Mar-Apr 2021;21:100191.doi: 10.1016/j.aohep.2020.03.003. Epub 2020 Mar 20.miRNA-338-3p/CAMK IIα signaling pathway prevents acetaminophen-induced acute liver inflammation in vivo.miRNA-338-3p/CAMKⅡα信号通路阻碍对乙酰氨基酚诱导的急性肝脏炎症

  47. Free Radic Biol Med. 2021 Aug 1;171:99-111.doi:10.1016/j.freeradbiomed.2021.05.012. Epub 2021 May 11. Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway大鼠蛛网膜下腔出血

  48. Neuroscience. 2021 Aug 1;468:199-210.doi:10.1016/j.neuroscience.2021.06.021. Epub 2021 Jun 21. Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder通过抑制神经炎症减轻认知缺陷

  49. J Thromb Thrombolysis. 2022 Jan;53(1):136-148. doi: 10.1007/s11239-021-02540-1. Epub 2021 Aug 5. Overexpression of miR-1298 attenuates myocardial ischemia-reperfusion injury by targeting PP2A

  50. Commun Biol . 2021 Aug 20;4(1):995.doi: 10.1038/s42003-021-02525-z.MicroRNA expression profile in Lampetra morii upon Vibrio anguillarum infection and miR-4561 characterization targeting lip

  51. ACS Chem Neurosci.2021 Jul 7;12(13):2399-2408.doi: 10.1021/acschemneuro.1c00131.Epub 2021 Jun 13.Participation of Mind Bomb-2 in Sevoflurane Anesthesia Induces Cognitive Impairment in Aged Mice via Modulating Ferroptosis.老年小鼠认知障碍

  52. Eur J Pharmacol.2021 Jul 15;903:174137.doi:10.1016/j.ejphar.2021. 174137.Epub 2021 Apr 30.RUNX1 regulates SMAD1 by transcriptionally activating the expression of USP9X, regulating the activation of hepatic stellate cells and liver fibrosis

  53. Cell Immunol. 2021 Jul;365:104382.doi: 10.1016/j.cellimm.2021.104382. Epub 2021 May 20.MicroRNA-26b-5p alleviates murine collagen-induced arthritis by modulating Th17 cell plasticity小RNA通过调控Th17细胞缓解小鼠胶原性关节炎

  54. Front Neurosci. 2021 Jul 13;15:663962.doi:10.3389/fnins.2021.663962. eCollection 2021. Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor大鼠神经炎性痛觉过敏

  55. Med Sci Monit. 2021 Jul 16;27:e929435.doi:10.12659/MSM.929435.lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent MannerlncRNA MEG3下调通过抑制氧化应激和炎症以miR-181b依赖的方式缓解脑出血

  56. Theranostics. 2021 Jul 13;11(16):8112-8128.doi:10.7150/thno.54961. eCollection 2021. CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancerENO1在胃癌中的泛素化作用

  57. Neuromolecular Med. 2021 Jun;23(2):267-284.doi: 10.1007/s12017-020-08611-5. Epub 2020 Aug 31.Galectin-9 Promotes Neuronal Restoration via Binding TLR-4 in a Rat Intracerebral Hemorrhage Model

  58. Mol Ther Nucleic Acids.2021 Mar 16;24:352-368.doi: 10.1016/j.omtn.2021.03.004.eCollection 2021 Jun 4.Circular RNA circMYBPC1 promotes skeletal muscle differentiation by targeting MyHC.环状RNA circMYBPC1通过靶向MyHC促进骨骼肌分化(IF:8.886).

  59. J Endocrinol Invest. 2022 Jan;45(1):17-28. doi: 10.1007/s40618-021-01606-4. Epub 2021 Jun 18. microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C

  60. Neurochem Res. 2021 Jun;46(6):1337-1349.doi:10.1007/s11064-021-03268-3. Epub 2021 Feb 16. Activated Microglia Exosomes Mediated miR-383-3p Promotes Neuronal Necroptosis Through Inhibiting ATF4 Expression in Intracerebral Hemorrhage脑出血

  61. Onco Targets Ther. 2021 Jun 9;14:3687-3700.doi:10.2147/OTT.S288788. eCollection 2021. miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3miR-210-3p通过调节USF1和PCGF3促进肺癌的发生和发展

  62. Mol Cell Biol. 2021 Jun 23;41(7):e0001621.doi:10.1128/MCB.00016-21. Epub 2021 Jun 23. MicroRNA 181a-2-3p Alleviates the Apoptosis of Renal Tubular Epithelial Cells via Targeting GJB2 in Sepsis-Induced Acute Kidney InjuryMicroRNA 181a-2-3p通过靶向GJB2减轻脓毒症急性肾损伤肾小管上皮细胞凋亡

  63. Front Immunol. 2021 Jun 7;12:637598. doi: 10.3389/fimmu.2021.637598. eCollection 2021. Overexpression of lncRNA TUG1 Alleviates NLRP3 Inflammasome-Mediated Cardiomyocyte Pyroptosis Through Targeting the miR-186-5p/XIAP Axis in Coronary Microembolization-Induced Myocardial Damage (IF:7.561).

  64. J Transl Med. 2021; 19: 223. Published online 2021 May 26. doi: 10.1186/s12967-021-02893-4miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitismiR-20a通过靶向Map3k9抑制Treg分化(IF:5.531).

  65. J Bone Miner Res. 2021 May;36(5):956-967.doi: 10.1002/jbmr.4253. Epub 2021 Feb 10.Cross-talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading

  66. Mol Immunol. 2021 May;133:23-33.doi: 10.1016/j.molimm.2021.02.008. Epub 2021 Feb 20. miRNA-467b inhibits Th17 differentiation by targeting eIF4E in experimental autoimmune encephalomyelitis脑脊髓炎

  67. Cancer Gene Ther. 2021 May 25.doi:10.1038/s41417-021-00306-8. Online ahead of print. LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1LncRNA MAFG-AS1促进卵巢癌的恶性表型

  68. J Bone Miner Res. 2021 May;36(5):956-967.doi:10.1002/jbmr.4253. Epub 2021 Feb 10. Cross-talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading组蛋白和DNA甲基化之间的相互作用介导后骨丢失

  69. Cell Mol Neurobiol. 2021 May;41(4):795-812.doi:10.1007/s10571-020-00887-2. Epub 2020 Jun 4. Miro1 Regulates Neuronal Mitochondrial Transport and Distribution to Alleviate Neuronal Damage in Secondary Brain Injury After Intracerebral Hemorrhage in Rats脑损伤

  70. Oxid Med Cell Longev.2021 Apr 9;2021:9034376.doi: 10.1155/2021/9034376.eCollection 2021.Hydromorphone Protects against CO 2 Pneumoperitoneum-Induced Lung Injury via Heme Oxygenase-1-Regulated Mitochondrial Dynamics.氢吗啡酮通过血红素加氧酶1调节的线粒体来保护二氧化碳气腹诱导的肺损伤。(IF:6.543).

  71. Front Neurosci.2021 Apr 7;15:657825.doi: 10.3389/fnins.2021.657825. eCollection 2021.β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension. β-Arrestin1通过激活延髓头端腹外侧区的Nrf2降低高血压患者的氧化应激反应

  72. Cancer Immunol Immunother. 2021 Apr;70(4):1015-1029.doi:10.1007/s00262-020-02741-2. Epub 2020 Oct 26. OSCC cell-secreted exosomal CMTM6 induced M2-like macrophages polarization via ERK1/2 signaling pathway巨噬细胞-瘤内注射

  73. CNS Neurosci Ther. 2021 Apr;27(4):449-463.doi: 10.1111/cns.13548. Epub 2020 Dec 12.Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis大鼠蛛网膜下腔出血后早期脑损伤中的有害作用

  74. Cent Eur J Immunol. 2021;46(1):17-26.doi:10.5114/ceji.2021.105242. Epub 2021 Apr 18.LncRNA MIAT enhances systemic lupus erythematosus by upregulating CFHR5 expression via miR-222 degradationLncRNA-MIAT增强系统性狼疮

  75. Stem Cell Res Ther. 2021 Mar 10;12(1):171.doi: 10.1186/s13287-021-02210-2.Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction.miR-133b调节结缔组织生长因子表达来治疗老年单侧输尿管梗阻小鼠肾间质纤维化(IF:6.832).

  76. Immun Inflamm Dis.2021 Mar;9(1):255-264.doi:10.1002/iid3.388.Epub 2020 Dec 3.Silenced SOX2-OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR-2355-3p

  77. J Cereb Blood Flow Metab. 2021 Mar;41(3):530-545.doi: 10.1177/0271678X20916860. Epub 2020 Apr 4.Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124继发性脑出血

  78. Theranostics. 2021 Mar 4;11(9):4531-4548.doi: 10.7150/thno.54803. eCollection 2021.The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists结肠?GLS1介导的谷氨酰胺解酶的作用

  79. Korean J Intern Med. 2021 Mar;36(Suppl 1):S160-S169.doi:10.3904/kjim.2019.098. Epub 2020 Jun 9. In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycinmicroRNA-155拮抗剂在博莱霉素诱导的小鼠肺纤维化模型中的体内治疗成功

  80. Cell Biosci. 2021 Feb 6;11(1):31.doi: 10.1186/s13578-020-00523-y.The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure.HDAC3、microRNA-18a和ADRB3在心力衰竭进展中的串扰.(IF:7.133).

  81. Neuroscience. 2021 Feb 16;S0306-4522(21)00085-3.doi:10.1016/j.neuroscience.2021.02.011. Online ahead of print. Early Growth Response Protein 1 Knockdown Alleviates the Cerebral Injury in Rats with Intracerebral Hemorrhage (ICH) via STAT3/NF-κB Pathway by Reducing RXRα Acetylation Level脑缺血

  82. Inflammation. 2021 Feb;44(1):217-228.doi:10.1007/s10753-020-01323-9. miR-30c-5p Alleviated Pyroptosis During Sepsis-Induced Acute Kidney Injury via Targeting TXNIPmiR-30c-5p通过靶向TXNIP减轻脓毒症诱导的急性肾损伤时的上睑下垂

  83. Gene. 2021 Feb 15;769:145253.doi:10.1016/j.gene.2020.145253. Epub 2020 Oct 22.FN1 promotes chondrocyte differentiation and collagen production via TGF-β/PI3K/Akt pathway in mice with femoral fractureFN1通过TGF促进软骨细胞分化和胶原生成

  84. Neuroscience. 2021 Feb 10;455:212-222. doi: 10.1016/j.neuroscience.2020.10.026. Epub 2020 Nov 13. Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus

  85. Exp Eye Res.2021 Jan;202:108361.doi: 10.1016/j.exer.2020.108361. Epub 2020 Nov 16.Novel insights into gene therapy in the cornea.角膜基因治疗的新见解

  86. Cell Death Dis. 2021 Jan 6;12(1):23.doi: 10.1038/s41419-020-03310-2. Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke防止小胶质细胞损伤可挽救的神经元

  87. Front Neurosci.2020 Dec 23;14:609613.doi: 10.3389/fnins.2020.609613. eCollection 2020.MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat.MiR-128-3p通过SP1抑制减轻大鼠脊髓缺血/再灌注损伤相关的神经炎症和细胞凋亡

  88. Cell Transplant.Jan-Dec 2020;29:963689720950226.doi: 10.1177/0963689720950226.6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and “cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats.

  89. Bioengineered.2020 Dec;11(1):547-557.doi: 10.1080/21655979.2020.1765501. miR-211 alleviates ischaemia/reperfusion-induced kidney injury by targeting TGFβR2/TGF-β/SMAD3 pathway. miR-211通过靶向TGFβR2/TGF-β/SMAD3途径减轻缺血/再灌注诱导的肾损伤

  90. Open Med (Wars).2020 Dec 24;15(1):1202-1212.doi: 10.1515/med-2020-0198.eCollection 2020. MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway

  91. Front Psychiatry.2020 Dec 18;11:576539.doi: 10.3389/fpsyt.2020.576539.eCollection 2020.ectroacupuncture Alleviates Cerebral Ischemia/Reperfusion Injury in Rats by Histone H4 Lysine 16 Acetylation-Mediated Autophagy电针通过组蛋白H4赖氨酸16乙酰化介导的自噬减轻大鼠脑缺血/再灌注损伤

  92. Exp Ther Med. 2020 Dec; 20(6): 230. Published online 2020 Oct 15. doi: 10.3892/etm.2020.9360ncRNA uc.48+ regulates immune and inflammatory reactions mediated by the P2X7 receptor in type 2 diabetic mice

  93. Am J Physiol Cell Physiol. 2020 Dec 1;319(6):C955-C966.doi: 10.1152/ajpcell.00481.2019.Epub 2020 Jun 3.miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model

  94. Brain Res Bull.2020 Dec;165:290-297.doi:10.1016/j.brainresbull.2020. 10.004.Epub 2020 Oct 20.Glucokinase in stellate ganglia cooperates with P2X3 receptor to develop cardiac sympathetic neuropathy in type 2 diabetes rats

  95. Pharmacol Res. 2020 Oct 5;105230. doi: 10.1016/j.phrs.2020.105230 Long noncoding RNA AK039312 and AK079370 inhibits bone formation via miR-199b-5p

  96. Brain Res Bull. 2020 Dec;165:169-177.doi:10.1016/j.brainresbull.2020.09.023. Epub 2020 Oct 11.
    Heterogeneous nuclear ribonucleoprotein A1 exerts protective role in intracerebral hemorrhage-induced secondary brain injury in rats

  97. Cell Cycle. 2020 Mar;19(6):684-696.doi:10.1080/15384101.2020.1717041. Epub 2020 Feb 23.
    Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats

  98. Exp Cell Res. 2020 Dec 9;398(2):112418.doi: 10.1016/j.yexcr.2020.112418.
    NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury

  99. Int Immunopharmacol. 2020 Nov;88:106848.doi:10.1016/j.intimp.2020.106848. Epub 2020 Aug 7. MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1MiRNA-133a通过靶向性作用加重脓毒症的炎症反应

  100. Aging (Albany NY).2020 Nov 18;13(10):14482-14498.doi: 10.18632/aging.103640.Epub 2020 Nov 18. irt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade. Irt1通过调节NF-κB p65/microRNA-155/BNDF信号级联改善心力衰竭

  101. J Neuroinflammation.2020 Nov 8;17(1):335.doi: 10.1186/s12974-020-02013-x.Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice(IF:8.322).

  102. Neuropsychiatr Dis Treat. 2020 Nov 12;16:2753-2764.doi:10.2147/NDT.S251152. eCollection 2020. MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3海马调节CUMS诱导的抑郁样行为

  103. Mol Med Rep. 2020 Nov;22(5):3944-3954.doi:10.3892/mmr.2020.11493. Epub 2020 Sep 7. miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTENmiR-183-5p减轻脑缺血损伤

  104. International Immunopharmacology Volume 88, November 2020, 106848
    MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1MiRNA-133a通过靶向SIRT1加重脓毒症的炎症反应

  105. Mol Cell Biochem. 2021 Jan;476(1):81-92. doi: 10.1007/s11010-020-03887-4. Epub 2020 Sep 4. LncRNA TTTY15 knockdown alleviates H 2 O 2-stimulated myocardial cell injury by regulating the miR-98-5p/CRP pathway

  106. 10.1159/000508210. Epub 2020 Nov 11.Protective Effect of miR-340-5p against Brain Injury after Intracerebral Hemorrhage by Targeting PDCD4.

  107. Int Immunopharmacol.2021 Jan;90:107039.doi: 10.1016/j.intimp.2020.107039.Epub 2020 Oct 28.LPS-induced vein endothelial cell injury and acute lung injury have Btk and Orai 1 to regulate SOC-mediated calcium influx.

  108. Front Pharmacol.2020 Sep 18;11:01187.doi: 10.3389/fphar.2020.01187. eCollection 2020.GLT25D2 Is Critical for Inflammatory Immune Response to Promote Acetaminophen-Induced Hepatotoxicity by Autophagy Pathway.炎症免疫反应

  109. Neuroscience.2020 May 1;433:212-220.doi: 10.1016/j.neuroscience.2020.03.013.Epub 2020 Mar 17. CXCR5 Knockdown Attenuates Hippocampal Neurogenesis Deficits and Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

  110. J Neuroinflammation. 2020 Oct 25;17(1):320.doi:10.1186/s12974-020-01970-7. Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy海马神经发生与认知功能

  111. Transl Stroke Res. 2020 Oct;11(5):1012-1027.doi:10.1007/s12975-019-00775-y. Epub 2020 Jan 6. Mfsd2a Attenuates Blood-Brain Barrier Disruption After Sub-arachnoid Hemorrhage by Inhibiting Caveolae-Mediated Transcellular Transport in Rats大鼠抑制小窝介导的蛛网膜下腔出血

  112. FASEB J. 2020 Oct;34(10):13548-13560.doi:10.1096/fj.202000246RR. Epub 2020 Aug 12. Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradationAngptl7促进胰岛素抵抗和2型糖尿病

  113. Cell Cycle. 2020 May;19(10):1122-1131.doi: 10.1080/15384101.2020.1748 949.Epub 2020 Apr 14Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539.长非编码RNA PCAT1通过miR-656和miR-539上调YAP,从而清除细胞肾细胞癌

  114. Mol Ther Nucleic Acids.2020 Sep 4;21:542-554.doi: 10.1016/j.omtn.2020.05.022.Epub 2020 May 22. erexpression of MicroRNA-340-5p Inhibits Pulmonary Arterial Hypertension Induced by APE by Downregulating IL-1β and IL-6.过表达MicroRNA-340-5p来下调IL-1β和IL-6的表达,抑制APE诱导的肺动脉高压(IF:8.886).

  115. Mol Med.2020 Nov 13;26(1):109.doi: 10.1186/s10020-020-00239-2.ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axisZLM-7通过miR-212-3p/Sp1/VEGFA信号轴抑制乳腺癌的发生和血管生成(IF:6.354).

  116. Front Cell Dev Biol.2020 Nov 5;8:572459.doi:10.3389/fcell.2020.572459.eCollection 2020.Transferrin Receptor Functionally Marks Thermogenic Adipocytes

  117. Acta Biochim Biophys Sin (Shanghai).2020 Sep 8;52(9):988-997.doi: 10.1093/abbs/gmaa078.Upregulation of miR-133a by adiponectin inhibits pyroptosis pathway and rescues acute aortic dissectio

  118. Mol Neurobiol.2020 Sep;57(9):3744-3758.doi: 10.1007/s12035-020-01990-7.Epub 2020 Jun 22.oles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes蛛网膜下腔出血

  119. Mol Cells.2020 Sep 30;43(9):793-803.doi:10.14348/molcells.2020.2307. 5.034.MicroRNA 449c Mediates the Generation of Monocytic Myeloid-Derived Suppressor Cells by Targeting STAT6

  120. Thromb Res. 2020 Sep;193:45-52.doi:10.1016/j.thromres.2020.05.030. Epub 2020 May 21. Rivaroxaban ameliorates angiotensin II-induced cardiac remodeling by attenuating TXNIP/Trx2 interaction in KKAy mice利伐沙班改善血管紧张素Ⅱ诱导的心脏重构

  121. Mol Cells. 2020 Sep 30;43(9):793-803.doi:10.14348/molcells.2020.2307. MicroRNA 449c Mediates the Generation of Monocytic 单核细胞髓源性抑制肿瘤细胞

  122. Br J Pharmacol.2020 Aug;177(16):3760-3777.doi: 10.1111/bph.15099. Epub 2020 Jun 27.Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.葡萄黄质通过上调FGF21/PGC-1α途径减轻非酒精性脂肪肝的肝损伤和线粒体功能障碍(IF:8.739).

  123. Theranostics.2020 Aug 29;10(24):10908-10924.doi: 10.7150/thno.48264. eCollection 2020.Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. 环状RNAcircPPM1F调节M1巨噬细胞的活化和胰岛炎症(IF:11.556).

  124. Front Physiol. 2020; 11: 846. Published online 2020 Aug 11. doi: 10.3389/fphys.2020.00846PRDM16 Upregulation Induced by MicroRNA-448 Inhibition Alleviates Atherosclerosis via the TGF-β Signaling Pathway Inactivation

  125. Biochem Biophys Res Commun.2020 Nov 5;532(2):271279.doi:10.1016/j.bb rc.2020.06.142.Epub 2020 Aug 29.Suppressing BRD4 exhibits protective effects against vincristine-induced peripheral neuropathy by alleviating inflammation and oxidative stress

  126. Biomed Pharmacother.2020Aug;128:110045.doi:10.1016/j.biopha.2020.110 045.Epub 2020 May 24.Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis Triad3A通过调节坏死性凋亡抑制脑缺血/再灌注(I/R)损伤过程中发挥关键作用

  127. Exp Mol Pathol. 2020 Aug;115:104475.doi: 10.1016/j.yexmp.2020.104475. Epub 2020 May 28.Remote ischemic postconditioning attenuates damage in rats with chronic cerebral ischemia by upregulating the autophagolysosome pathway via the activation of TFEB

  128. Aging (Albany NY).2020 Jul 9;12(13):13234-13254.doi: 10.18632/aging.103431.Epub 2020 Jul 9.Increasing the expression of microRNA-126-5p in the temporal muscle can promote angiogenesis in the chronically ischemic brains of rats subjected to two-vessel occlusion plus encephalo-myo-synangiosis.大老鼠慢性缺血脑

  129. Theranostics. 2020; 10(18): 8430–8445.Published online 2020 Jul 9. doi: 10.7150/thno.44370Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21(IF:11.556).

  130. J Mol Neurosci. 2021 Jan;71(1):9-18. doi: 10.1007/s12031-020-01619-3. Epub 2020 Jul 20. RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats

  131. Int Arch Allergy Immunol. 2020;181(8):594-605.doi:10.1159/000507250. Epub 2020 Jul 1. Divergent Roles of miR-3162-3p in Pulmonary Inflammation in Normal and Asthmatic Mice as well as Antagonism of miR-3162-3p in Asthma Treatment肺纤维化哮喘

  132. Cell Signal. 2020 Jul;71:109570.doi:10.1016/j.cellsig.2020.109570. Epub 2020 Feb 19. Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2miR-203对荷瘤小鼠血管生成的抑制作用

  133. BRITISH JOURNAL OF PHARMACOLOGY Volume177, Issue14 July 2020 Pages 3258-3272
    Source of dopamine in gastric juice and luminal dopamine‐induced duodenal bicarbonate secretion via apical dopamine D2 receptors胃液中多巴胺的来源及多巴胺诱导的十二指肠

  134. Metab Brain Dis. 2020 Jun;35(5):753-763.doi:10.1007/s11011-020-00544-z. Epub 2020 Feb 21. Neuroprotective effects of miR-532-5p against ischemic strokemiR-532-5p对缺血性卒中的神经保护作用

  135. Korean J Intern Med. 2021 Mar;36(Suppl 1):S160-S169. doi: 10.3904/kjim.2019.098. Epub 2020 Jun 9. In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin

  136. Eur J Pharmacol doi: 10.1016/j.ejphar.2020.173162.Epub 2020 May 11. Na +-K +-2Cl – cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice.位于人和小鼠胃粘膜中的Na+-K+-2Cl-共转运蛋白2参与促泌素诱导的胃酸分泌过程,并在脂多糖治疗的小鼠中表达下调。

  137. Onco Targets Ther. 2020; 13: 3789–3800. Published online 2020 May 5. doi: 10.2147/OTT.S245346.miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer.

  138. Front. Oncol., 30 April 2020. Identification Hub Genes in Colorectal Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Clinical Validation in vivo and vitro

  139. Biochem Pharmacol.2020 Apr;174:113822.doi: 10.1016/j.bcp.2020.113822. Epub 2020 Jan 25.MicroRNA let-7g-5p alleviates murine collagen-induced arthritis by inhibiting Th17 cell differentiationMicroRNA let-7g-5p通过抑制Th17细胞分化减轻小鼠胶原诱导的关节炎

  140. Neurochem Int.2020 Mar;134:104656.doi: 10.1016/j.neuint.2019.104656. Epub 2019 Dec 31. Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C.

  141. Exp Cell Res.2020 Mar 1;388(1):111801.doi: 10.1016/j.yexcr.2019.111801.Epub 2019 Dec 23.Interleukin 9 prevents immune thrombocytopenia in mice via JAK/STAT5 signaling白细胞介素9通过JAK/STAT5信号通路预防小鼠免疫性血小板减少

  142. Mol Med Rep.2020 Mar;21(3):1145-1153.doi: 10.3892/mmr.2019.10903. Epub 2019 Dec 23.miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.miR-222通过靶向ITGB8调节脑出血后的脑损伤和炎症

  143. Exp Ther Med. 2020 Mar;19(3):2029-2036.doi:10.3892/etm.2020.8456. Epub 2020 Jan 15.Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat modelAQP4 RNAi在治疗创伤性脑水肿中的作用:大鼠模型早期水肿的多模式MRI和组织病理学变化

  144. Biochem Biophys Res Commun. 2020 Mar 19;523(4):931-938.doi:10.1016/j.bbrc.2020.01.029. Epub 2020 Jan 18. Inhibition of miR-200b-3p alleviates hypoxia-ischemic brain damage via targeting Slit2 in neonatal rats减轻缺氧缺血性脑损伤

  145. Biomed Pharmacother. 2020 Mar;123:109761.doi:10.1016/j.biopha.2019.109761. Epub 2019 Dec 19. CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-κB signalingCRBN基因敲除减轻脂多糖诱导的急性肺损伤

  146. Mol Med Rep. 2020 Feb;21(2):795-805.doi: 10.3892/mmr.2019.10870.Epub 2019 Dec 6.BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF‑κB signaling pathway in glomerular mesangial cells.BAFF通过激活肾小球系膜细胞中的TRAF6/NF-κB信号通路参与IgA肾病的发病机制

  147. Anim Reprod Sci.2020 Apr;215:106332.doi: 10.1016/j.anireprosci.2020.106332.Epub 2020 Feb 25.Molecular characteristics and abundance of insulin-like androgenic gland hormone and effects of RNA interference in Eriocheir sinensis

  148. Cell Prolif. 2020 Feb;53(2):e12744.doi: 10.1111/cpr.12744. Epub 2019 Dec 15. MLL1 promotes myogenesis by epigenetically regulating Myf5肌肉注射

  149. Mol Ther Nucleic Acids.2020 Jun 5;20:292-307.doi: 10.1016/j.omtn.2019.12.027.Epub 2020 Jan 10.mmu_circ_0000790 Is Involved in Pulmonary Vascular Remodeling in Mice with HPH via MicroRNA-374c-Mediated FOXC1.mmu_circ_0000790通过MicroRNA-374c介导的FOXC1参与HPH小鼠肺血管重塑(IF:8.886).

  150. Biochem Biophys Res Commun. 2020 Jan 15;521(3):569-576.doi:10.1016/j.bbrc.2019.09.111. Epub 2019 Oct 31. Progranulin protects against cerebral ischemia-reperfusion (I/R) injury by inhibiting necroptosis and oxidative stress脑缺血再灌注损伤

  151. Int J Mol Sci.2019 Dec 10;20(24):6229.doi: 10.3390/ijms20246229. Silencing of lncRNA AK045490 Promotes Osteoblast Differentiation and Bone Formation via β-Catenin/TCF1/Runx2 Signaling Axis.

  152. Oxid Med Cell Longev.2019 Dec 24;2019:7838754.doi: 10.1155/2019/7838754.eCollection 2019.IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart.(IF:6.543).

  153. Bone Joint Res. 2019 Dec 3;8(11):550-562.doi: 10.1302/2046-3758.811.BJR-2018-0251.R1. eCollection 2019 Nov.MicroRNA-186 improves fracture healing through activating the bone morphogenetic protein signalling pathway by inhibiting SMAD6 in a mouse model of femoral fracture: An animal study.在小鼠股骨骨折模型中,MicroRNA-186通过抑制SMAD6,激活骨形态蛋白信号通路,从而促进骨折愈合:一项动物研究.(IF:5.853).

  154. Mol Brain.2019 Dec 3;12(1):102.doi: 10.1186/s13041-019-0523-7. Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1.沉默microRNA-146a使Notch-1表达降低从而减轻颞叶癫痫的神经损伤。

  155. Transl Stroke Res.2019 Dec;10(6):729-743.doi:10.1007/s12975-019-00702-1.Epub 2019 Apr 2. Exploration of MST1-Mediated Secondary Brain Injury Induced by Intracerebral Hemorrhage in Rats via Hippo Signaling Pathway.大鼠脑出血诱导的Hippo信号通路.(IF:6.829).

  156. Mol Ther Nucleic Acids. 2019 Dec 6;18:1-15.doi: 10.1016/j.omtn.2019.08.003. Epub 2019 Aug 12. (IF:5.919).
    lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway (lnc-3215与低硒鸡心脏损伤钙超载研究)

  157. Biochem Biophys Res Commun. 2019 Nov 12;519(3):445-452.doi: 10.1016/j.bbrc.2019.07.091. Epub 2019 Sep 13.
    Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKα-dependent manner(破骨细胞生成和骨丢失研究)

  158. Front Psychiatry . 2019 Oct 18;10:770. doi: 10.3389/fpsyt.2019.00770. eCollection 2019.Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X 7 Receptor

  159. World Neurosurg. 2019 Oct;130:e54-e61. doi: 10.1016/j.wneu.2019.05.194. Epub 2019 May 29.erebral Ischemia/Reperfusion Injury in Stroke Patients and a Mouse Model.

  160. Life Sci. 2019 Oct 15;235:116822.doi: 10.1016/j.lfs.2019.116822. Epub 2019 Aug 30.
    Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats(mfhas1对脓毒症大鼠认知功能障碍及海马树突病理的影响研究)

  161. Mol Ther Nucleic Acids.2019 Sep 6;17:891-906.doi: 10.1016/j.omtn.2019.07.017.Epub 2019 Aug 1.Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide.使用改良细胞穿透肽在完整角膜上皮中能够有效地局部递送siRNA实现基因沉默(IF:8.886).

  162. Exp Neurol. 2019 Nov;321:113028. doi: 10.1016/j.expneurol.2019.113028. Epub 2019 Aug 1.Botch protects neurons from ischemic insult by antagonizing Notch-mediated neuroinflammation.Botch通过拮抗Notch介导的神经炎症保护神经元免受缺血损伤(IF:5.330).

  163. Neurobiol Dis.2019 Sep;129:144-158. doi: 10.1016/j.nbd.2019.05.004.
    RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis(RIP3与大鼠实验性蛛网膜下腔出血后早期脑损伤研究)

  164. Biosci Rep.2019 Sep 9;39(9):BSR20190432.doi: 10.1042/BSR20190432. Print 2019 Sep 30. Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats.细胞外调节激酶5通过调节去卵巢大鼠成骨细胞的活力和凋亡介导骨质疏松.

  165. Life Sci.2019 Nov 15;237:116769.doi: 10.1016/j.lfs.2019.116769.Epub 2019 Aug 15.LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1.

  166. Biomed Pharmacother.2019 Sep;117:109155.doi: 10.1016/j.biopha.2019.109155.Epub 2019 Jul 1.CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress.CFLAR通过调节炎症和内质网应激,成为脑缺血再灌注损伤的重要调节因子(IF:6.529).

  167. Aging (Albany NY).2019 Sep 20;11(18):7570-7586.doi: 10.18632/aging.102272.Epub 2019 Sep 20. Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation. miR-93的上调和LIMK1的抑制表达通过抑制RhoA/ROCK信号通路的激活来改善慢性心力衰竭大鼠心室重构和减轻心功能不全

  168. Nat Commun. 2019 Sep 20;10(1):4303.doi: 10.1038/s41467-019-12351-x. (IF:12.121).
    Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction.(肝胰高血糖素反应研究)

  169. Cell Death Dis. 2019 Sep 11;10(9):670.doi: 10.1038/s41419-019-1873-x. (IF:5.959).
    Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis(肌成纤维细胞分化和肺纤维化研究)

  170. Front Neurosci.2019 Aug 16;13:866.doi: 10.3389/fnins.2019.00866. eCollection 2019.MicroRNA-126-3p Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Regulating VCAM-1 Expression.

  171. Biochem Biophys Res Commun.2019 Aug 6;515(4):651-657.doi: 10.1016/j.bbrc.2019.05.065.Epub 2019 Jun 6.eperfusion injury through regulating apoptosis and inflammation. Trim47可以调节细胞凋亡和炎症,是脑缺血再灌注损伤的关键调节因子

  172. Redox Biol . 2019 Jul;25:101196. doi: 10.1016/j.redox.2019.10119.
    Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway(肠上皮细胞G1期阻滞研究)

  173. Auton Neurosci.2019 Jul;219:33-41.doi: 10.1016/j.autneu.2019.03.005. Epub 2019 Mar 26.Effects of chronic lead exposure on the sympathoexcitatory response associated with the P2X7 receptor in rat superior cervical ganglia.

  174. J Cancer.2019 Jul 8;10(17):4085-4095. doi: 10.7150/jca.30012.
    Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer(非小细胞肺癌研究)

  175. Brain Res Bull.2019 Jul;149:216-221.doi:10.1016/j.brainresbull.2019.04.024.Epub 2019 Apr 30. bnormal sympathetic activity after myocardial ischemia involving P2X4 in dorsal root ganglia.

  176. Biochem Biophys Res Commun .2019 Jun 25;514(2):558-564. doi: 10.1016/j.bbrc.2019.04.086.
    FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK(FBXW5与脊髓损伤研究)

  177. Cell Transplant.2019 Jun;28(6):723-738.doi: 10.1177/0963689718817219. Epub 2018 Dec 4.Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro.脑出血诱导的继发性脑损伤中的有害作用

  178. J Cell Physiol . 2019 Jul;234(7):11524-11536. doi: 10.1002/jcp.27815.
    A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation(LncRNA AK016739抑制成骨细胞分化和骨形成)

  179. Osteoarthritis Cartilage . 2019 Jun;27(6):922-931. doi:10.1016/j.joca.2019.01.012.
    Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB(Clock突变体和骨关节炎研究)

  180. EBioMedicine.2019 Jun;44:439-451. doi: 10.1016/j.ebiom.2019.05.041
    MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma(microrna-200b与肾癌转移研究)

  181. Neuroscience . 2019 Jun 15;409:43-57. doi: 10.1016/j.neuroscience.2019.04.041.
    NEMO-binding domain peptides alleviate perihematomal inflammation injury after experimental intracerebral hemorrhage(实验性脑出血后血周炎症损伤研究)

  182. Cell Death Dis.2019 Jun 5;10(6):441. doi: 10.1038/s41419-019-1631-0.
    Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model(缺血小鼠神经元凋亡调控研究)

  183. Aging (Albany NY).2019 May 7;11(9):2762-2786.doi: 10.18632/aging.101948.MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

  184. Cell Tissue Res.2019 Oct;378(1):67-80.doi: 10.1007/s00441-019-03026-6.Epub 2019 May 18.Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model.miR-943-3p对哮喘小鼠模型分泌型卷曲相关蛋白4(SFRP4)的干扰作用.(IF:5.249).

  185. Brain Behav Immun . 2019 May;78:188-201. doi: 10.1016/j.bbi.2019.01.020
    MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice(小鼠手术创伤引起的认知功能下降研究)

  186. Exp Neurol . 2019 May;315:21-31. doi:10.1016/j.expneurol.2019.01.018.

    GATA-4 regulates neuronal apoptosis after intracerebral hemorrhage via the NF-κB/Bax/Caspase-3 pathway both in vivo and in vitro(GATA-4调节脑出血后神经元凋亡)

  187. J Am Heart Assoc. 2019 May 7;8(9):e011851.doi: 10.1161/JAHA.118.011851.el Role of Carbon Monoxide in Improving Neurological Outcome After Cardiac Arrest in Aged Rats: Involvement of Inducing Mitochondrial Autophagy.一氧化碳在改善老年大鼠心脏骤停后神经功能方面的新作用:参与诱导线粒体自噬

  188. J Mol Neurosci.2019 May;68(1):144-152.doi: 10.1007/s12031-019-01293-0.Epub 2019 Mar 20.Neuroprotective Influence of miR-301a Inhibition in Experimental Cerebral Ischemia/Reperfusion Rat Models Through Targeting NDRG2.

  189. Cell Mol Immunol . 2019 May;16(5):483-494. doi: 10.1038/s41423-018-0033-z.
    Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin(骨桥蛋白代谢对乙酰氨基酚肝毒性的调节作用研究)

  190. Bioconjug Chem . 2019 May 15;30(5):1459-1465. doi: 10.1021/acs.bioconjchem.9b00204.
    Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice(笼状siRNA和光化学调控RNAi诱导的小鼠基因沉默研究)

  191. FASEB J. 2019 Apr;33(4):5112-5125.doi: 10.1096/fj.201801111RR.Epub 2019 Jan 17.Long noncoding RNA AK089579 inhibits epithelial-to-mesenchymal transition of peritoneal mesothelial cells by competitively binding to microRNA-296-3p via DOK2 in peritoneal fibrosis.在腹膜纤维化中,长非编码RNA AK089579通过DOK2与microRNA-296-3p的竞争性结合抑制腹膜间皮细胞上皮向间充质转化.(IF:5.191).

  192. Exp Ther Med. 2019 Apr;17(4):3117-3123.doi: 10.3892/etm.2019.7322.Epub 2019 Feb 26.NL1 expression level in Nrx1β and the excitability of PV interneurons in mice with POCD.术后认知功能障碍小鼠NL1表达水平与小白蛋白的中间神经元兴奋性

  193. J Cell Physiol. 2019 Apr;234(4):3720-3729.doi: 10.1002/jcp.27146. Epub 2018 Oct 14.
    MiR-208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A (mir‐208b通过靶向cdkn1a调节细胞周期并促进骨骼肌细胞增殖)

  194. Free Radic Biol Med. 2019 Apr;134:23-41.doi: 10.1016/j.freeradbiomed.2018.12.034. Epub 2018 Dec 30.
    Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress(RIP3的缺失和非酒精性脂肪肝疾病研究)(IF:6.020).

  195. Am J Physiol Gastrointest Liver Physiol.2019 Apr 1;316(4):G539-G550. doi:10.1152/ajpgi.00249.2018.Epub 2019 Feb 8.lncRNA GAS5 restrains CCl 4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. lncRNA GAS5通过PTEN/PI3K/Akt信号通路靶向miR-23a,抑制CCl4诱导的肝纤维化。

  196. J Cell Biochem.2019 Mar;120(3):4238-4247.doi: 10.1002/jcb.27709.Epub 2018 Sep 30.Role of high-mobility group B1 in myocardial injury induced by coronary microembolization in rats高迁移率族B1在大鼠冠状动脉微栓塞心肌损伤中的作用

  197. J Cell Biochem. 2019 Mar;120(3):2847-2858.doi: 10.1002/jcb.26567. Epub 2018 Nov 30.
    Effects of microrna-93 on mouse cardiac microvascular endothelial cells injury and inflammatory response by mediating SPP1 through the NF-ΚB pathway (microRNA‐93与小鼠心肌微血管内皮细胞损伤研究)

  198. Dev Comp Immunol. 2019 Mar;92:150-159.doi: 10.1016/j.dci.2018.11.006. Epub 2018 Nov 11.
    Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection (半滑舌鳎脾脏巨核细胞病毒诱导蛋白)

  199. J Cell Biochem. 2019 Mar;120(3):2973-2982.doi: 10.1002/jcb.27025. Epub 2018 Dec 5.
    miR-202 modulates the progression of neuropathic pain through targeting RAP1A (Mir-202通过靶向RAP1A调节神经性疼痛的进展 )

  200. Exp Neurol. 2019 Mar;313:37-48.doi: 10.1016/j.expneurol.2018.12.003. Epub 2018 Dec 5. Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury (大鼠脑外伤后大脑皮层环状RNA变化研究)(IF:4.483).

  201. Biomed Pharmacother.2019 Mar;111:468-475.doi: 10.1016/j.biopha.2018.12.105.Epub 2018 Dec 27.Kaempferol protects mice from d-GalN/LPS-induced acute liver failure by regulating the ER stress-Grp78-CHOP signaling pathway.山奈酚通过调节内质网应激-Grp78-CHOP信号通路保护d-GalN/LPS诱导的小鼠急性肝衰竭(IF:6.529).

  202. Front Cell Neurosci.2019 Mar 26;13:117.doi: 10.3389/fncel.2019.00117. eCollection 2019.Semaphorin 3A Contributes to Secondary Blood-Brain Barrier Damage After Traumatic Brain Injury.信号蛋白3A参与创伤性脑损伤后继发性血脑屏障损伤过程(IF:5.505).

  203. Immunol Lett. 2019 Feb;206:1-10.doi: 10.1016/j.imlet.2018.11.014. Epub 2018 Nov 29. miR-181b regulates ER stress induced neuron death through targeting Heat Shock Protein A5 following intracerebral haemorrhage.神经元死亡

  204. Front Mol Neurosci.2019 Feb 22;12:42.doi: 10.3389/fnmol.2019.00042. eCollection 2019. atrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury.苯甲酸钠通过Akt磷酸化和DJ-1相关抗氧化应激途径减轻大鼠创伤性脊髓损伤模型中的神经元凋亡

  205. Front Genet. 2019 Feb 19;10:112.doi: 10.3389/fgene.2019.00112. eCollection 2019. Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus

  206. Anticancer Drugs 2019 Jan;30(1):38-45.doi: 10.1097/CAD.0000000000000687.Increased miR-203-3p and reduced miR-21-5p synergistically inhibit proliferation, migration, and invasion in esophageal cancer cells.增加miR-203-3p和减少miR-21-5p协同抑制食管癌细胞的增殖、迁移和侵袭。

  207. Biochem Biophys Res Commun. 2019 Jan 15;508(3):701-708.doi: 10.1016/j.bbrc.2018.11.072. Epub 2018 Dec 5.
    Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity (脂多糖(LPS)诱导的急性肺损伤)

  208. Br J Pharmacol. 2019 Feb;176(3):400-415.doi: 10.1111/bph.14537. Epub 2018 Dec 18. Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke(荷花碱通过调节nrf2信号对缺血性卒中线粒体的保护作用 )(IF:6.810).

  209. Int J Clin Exp Pathol.2019 Jun 1;12(6):2157-2165.eCollection 2019. nhibition of CLU4A exhibits a cardioprotective role in hypoxia/reoxygenation-induced injury by an ERK-dependent pathway.

  210. Biochem Biophys Res Commun.2019 Jun 25;514(2):550-557.doi: 10.1016/j.bbrc.2019.04.161.Epub 2019 May 3. Long non-coding RNA CHRF modulates the progression of cerebral ischemia/reperfusion injury via miR-126/SOX6 signaling pathway.长链非编码RNA CHRF通过miR-126/SOX6信号通路调节脑缺血/再灌注损伤的发展

  211. Mol Med Rep.2019 Jan;19(1):327-337.doi: 10.3892/mmr.2018.9640.Epub 2018 Nov 9. N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats.

  212. J Neuroinflammation . 2019 Jan 15;16(1):8. doi: 10.1186/s12974-019-1396-5.
    Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch(间充质干细胞减轻蛛网膜下腔出血早期脑损伤)

  213. J Exp Clin Cancer Res. 2019 Jan 10;38(1):14.doi: 10.1186/s13046-018-0985-y.
    Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer (有核梭杆菌与直肠癌中5-氟尿嘧啶的化疗抗性)

  214. Development. 2018 Dec 17;145(24):dev170670.doi: 10.1242/dev.170670.The microRNAs let-7 and miR-278 regulate insect metamorphosis and oogenesis by targeting the juvenile hormone early-response gene Krüppel-homolog 1

  215. CNS Neurosci Ther. 2018 Oct;24(10):906-916.doi: 10.1111/cns.12833. Epub 2018 Feb 27.
    Inhibition of Lats1/p‐YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.(大鼠创伤性脑损伤模型中神经元凋亡和神经功能障碍研究)

  216. Mol Imaging Biol. 2018 Oct;20(5):761-770.doi: 10.1007/s11307-018-1180-4.
    Bioluminescence Imaging for Monitoring miR-200c Expression in Breast Cancer Cells and its Effects on Epithelial-Mesenchymal Transition Progress in Living Animals.(mir-200c在乳腺癌细胞上皮间质转化中作用研究)

  217. J Cell Physiol. 2018 Sep;233(9):6615-6631.doi: 10.1002/jcp.26274. Epub 2018 Mar 25.
    miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin (miR‐34b‐5p与急性肺损伤研究)

  218. Cell Death Dis. 2018 Sep 20;9(10):962.doi: 10.1038/s41419-018-1021-z.A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth

  219. Can J Physiol Pharmacol. 2018 Jun;96(6):611-617.doi: 10.1139/cjpp-2017-0586. Epub 2018 Mar 5.
    The role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury.(microRNA-146a在调控脑缺血-再灌注损伤中IRAK1表达的作用研究)

  220. Bone. 2018 Jun;111:82-91.doi: 10.1016/j.bone.2018.03.017. Epub 2018 Mar 16.
    Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis (DNMT1过表达和废用性骨质疏松研究)

  221. Biomaterials. 2018 May;165:48-55.doi: 10.1016/j.biomaterials.2018.02.045. Epub 2018 Feb 24.
    Hypoxia-inducible Factor-1α directs renal regeneration induced by decellularized scaffolds.(DNA甲基转移酶3a与乙型肝炎病毒研究)

  222. Biofactors.2018 May 24.doi: 10.1002/biof.1433. Online ahead of print. MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/MDM-2/p53 pathway after traumatic spinal cord injury in rats

  223. Neuroscience. 2018 Mar 15;374:214-222.doi: 10.1016/j.neuroscience.2018.01.049. Epub 2018 Feb 5.
    Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats.(LncRNA BC168687参与TRPV1受体介导的糖尿病大鼠神经病理性疼痛)

  224. Purinergic Signal. 2018 Mar;14(1):47-58.doi: 10.1007/s11302-017-9594-z. Epub 2017 Nov 20.
    P2Y 12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2′,3′-dideoxycytidine (卫星胶质细胞中P2Y12受体上调与神经性疼痛研究)

  225. Mol Ther Nucleic Acids. 2018 Mar 2;10:237-244.doi: 10.1016/j.omtn.2017.12.007. Epub 2017 Dec 19.
    Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice.(环状siRNA与基因脱靶效应研究)

  226. Neurobiol Dis. 2018 Feb;110:82-92.doi: 10.1016/j.nbd.2017.11.012. Epub 2017 Dec 2.
    Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats (膜联蛋白A7在大鼠继发性脑损伤中的作用研究)

  227. Front Cell Neurosci. 2018 Jan 11;11:432.doi: 10.3389/fncel.2017.00432. eCollection 2017.
    Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.(神经轴突导向因子netrin-1与大鼠实验性脑出血后继发性脑损伤中的神经保护作用研究)

  228. Evid Based Complement Alternat Med. 2018 Jan 9;2018:6139372.doi: 10.1155/2018/6139372. eCollection 2018.
    The Protective Effect of Total Flavones from Rhododendron simsii Planch. on Myocardial Ischemia/Reperfusion Injury and Its Underlying Mechanism.(杜鹃花总黄酮对心肌缺血再灌注损伤保护作用)

  229. Cell Death Dis. 2018 Jan 9;9(1):11.doi: 10.1038/s41419-017-0014-7.
    miRNA-3473b contributes to neuroinflammation following cerebral ischemia.(miRNA-3473b导致脑缺血后神经炎症)

  230. Exp Cell Res. 2017 Dec 15;361(2):342-352.doi: 10.1016/j.yexcr.2017.11.002. Epub 2017 Nov 2.
    Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.(促红细胞生成素与蛛网膜下腔出血早期脑损伤研究)

  231. Cell Death Dis. 2017 Dec 13;8(12):3211.doi: 10.1038/s41419-017-0047-y.
    Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway (LncRNA MEG3与缺血性神经元死亡研究)

  232. Cell Mol Neurobiol. 2017 Nov;37(8):1457-1464.doi: 10.1007/s10571-017-0476-2. Epub 2017 Feb 25.
    Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. (siRNA侧脑室注射研究小鼠脓毒症相关脑病引起的认知功能障碍)

  233. Chem Sci. 2017 Oct 19;9(1):44-51.doi: 10.1039/c7sc03842a. eCollection 2018 Jan 7.
    Caged circular siRNAs for photomodulation of gene expression in cells and mice (环状RNA与基因表达光调控)

  234. Neurol Res. 2017 Sep;39(9):795-802.doi: 10.1080/01616412.2017.1321710. Epub 2017 May 1.
    The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains.(15-LO-1siRNA通过在小鼠缺血性脑中上调VEGF来促进血管生成)

  235. J Neurochem. 2017 Aug;142(3):478-492.doi: 10.1111/jnc.14075. Epub 2017 Jun 20.
    Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress (大鼠蛛网膜下腔出血与早期脑损伤)

  236. Biochem Biophys Res Commun. 2017 Aug 5;489(4):386-392.doi: 10.1016/j.bbrc.2017.05.136. Epub 2017 May 25.
    Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy (长链非编码RNA与乳腺癌治疗)

  237. Mediators Inflamm. 2017;2017:1570917.doi: 10.1155/2017/1570917. Epub 2017 Feb 15.
    Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. (大鼠实验性弥漫性轴索损伤)

  238. EBioMedicine. 2017 May;19:49-59.doi: 10.1016/j.ebiom.2017.04.017. Epub 2017 Apr 11.
    Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy.(siRNA与小鼠肺腺癌骨转移研究)

  239. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):656-663.doi: 10.1111/1440-1681.12742.
    Limb remote ischaemic postconditioning-induced elevation of fibulin-5 confers neuroprotection to rats with cerebral ischaemia/reperfusion injury: Activation of the AKT pathway (AKT通路与大鼠大脑局部缺血/再灌注损伤)

  240. Blood. 2017 Jun 15;129(24):3196-3209.doi: 10.1182/blood-2016-11-749838. Epub 2017 Apr 27. (IF:11.841). Osteoblasts support megakaryopoiesis through production of interleukin 9.(成骨细胞与白介素9研究)

  241. Oncotarget. 2017 May 30;8(47):82064-82077.doi: 10.18632/oncotarget.18289. eCollection 2017 Oct 10. (IF:5.168).
    MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress (肾小管上皮细胞凋亡)

  242. Can J Physiol Pharmacol. 2017 Apr;95(4):437-442.doi: 10.1139/cjpp-2016-0248. Epub 2016 Nov 24.
    miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of TGF-β1/Smad/CTGF signaling pathway.(miR-29b通过抑制TGF-β1/ Smad / CTGF信号通路促进皮肤伤口愈合并减少过度瘢痕形成)

  243. J Bone Miner Res. 2017 Feb;32(2):319-332.doi: 10.1002/jbmr.2992. Epub 2017 Jan 3.(IF:5.622).
    TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt pathway in Steroid-Associated Osteonecrosis (TET3介导类固醇相关性骨坏死中表观遗传标记5hmC和Akt途径的改变)

  244. Exp Ther Med. 2016 Dec;12(6):4121-4127.doi: 10.3892/etm.2016.3900. Epub 2016 Nov 14.
    Role of miR-145 in chronic constriction injury in rats.(miR-145在大鼠慢性压迫性损伤中的作用)

  245. Int Immunopharmacol. 2016 Nov;40:339-346.doi: 10.1016/j.intimp.2016.09.011. Epub 2016 Sep 24.
    Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation(miR-155与乙酰氨基酚诱导的肝脏炎症)

  246. Genet Test Mol Biomarkers. 2016 Nov;20(11):645-653.doi: 10.1089/gtmb.2016.0011. Epub 2016 Sep 27.
    Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis.(miR-98上调可抑制骨关节炎中软骨细胞凋亡)

  247. J Cell Sci. 2016 Nov 15;129(22):4305-4316.doi: 10.1242/jcs.189944. Epub 2016 Sep 26. (IF:5.168).
    HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2 (HMGB2通过IGF2BP2调节卫星细胞介导的骨骼肌再生)

  248. Exp Eye Res. 2016 Oct;151:134-41.doi: 10.1016/j.exer.2016.08.010. Epub 2016 Aug 25.
    CD25 siRNA induces Treg/Th1 cytokine expression in rat corneal transplantation models( CD25 siRNA诱导大鼠角膜移植模型中的Treg / Th1细胞因子表达)

  249. Arthritis Rheumatol. 2016 Sep;68(9):2232-43.doi: 10.1002/art.39725. (IF:6.009).
    MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells.(miR-130b通过靶向I型干扰素通路作用于肾脏固有细胞从而改善小鼠狼疮性肾)

  250. J Cardiovasc Pharmacol Ther. 2016 Sep;21(5):471-7.doi: 10.1177/1074248415624158. Epub 2016 Feb 4.
    The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization(PTEN / Akt信号通路介导猪冠状动脉微栓塞后心肌细胞凋亡)

  251. Int J Clin Exp Pathol 2016;9(3):3125-3133
    Original Article Regulation of ZNF580 in pathogenesis of ischemic cerebrovascular disease accompanied with upregulation of Smad2 and ADNP( 在伴随着Smad2和ADNP上调缺血性脑血管病的发病机制中ZNF580的调节)

  252. Sci Rep. 2016 Sep 19;6:33577.doi: 10.1038/srep33577. (IF:5.228).
    Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.(蛛网膜下腔出血和小鼠大脑损伤)

  253. Cell Physiol Biochem. 2016;38(1):207-19.doi: 10.1159/000438622. Epub 2016 Jan 20.
    Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway.(阿托伐他汀通过调节PTEN/PI3K/Akt信号通路抑制冠状动脉微栓塞模型猪心肌细胞凋亡)

  254. Cell Physiol Biochem. 2016;38(2):836-46.doi: 10.1159/000443038. Epub 2016 Feb 24.
    Upregulation of Long Non-Coding RNA PlncRNA-1 Promotes Metastasis and Induces Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.(长链非编码RNA PlncRNA-1的上调可以促进并诱导肝癌细胞上皮间质之间转化)

  255. Int J Mol Med. 2016 Jul;38(1):113-22.doi: 10.3892/ijmm.2016.2619. Epub 2016 May 31.
    miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression.(miR-1通过MET,细胞周期蛋白D1和CDK4表达的下调在体内和体外抑制食管鳞状细胞癌的生长)

  256. Int J Biochem Cell Biol. 2016 Jun;75:11-22.doi: 10.1016/j.biocel.2016.03.008. Epub 2016 Mar 18.
    Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-βactivated kinase-1 binding protein-1 signaling pathway.(ω-3脂肪酸对大鼠蛛网膜下腔出血早期脑损伤的抑制作用)

  257. Oncotarget. 2016 Jun 14;7(24):37192-37204.doi: 10.18632/oncotarget.9293.
    Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine (抑制Bmi1可以增强胰腺癌细胞对gemcitabine的敏感性)

  258. Sci Rep. 2016 Jun 29;6:28776.doi: 10.1038/srep28776. (IF:5.228).
    Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV) (土拨鼠肝炎病毒感染的土拨鼠中IFI16和AIM2的分子鉴定及表达)

  259. Chinese Journal of Biochemistry and Molecular Biology. 2016 Jun 9.
    过表达微小RNA miR-125b抑制肝癌细胞上皮-间质转换及促进细胞凋亡

  260. Am J Cancer Res. 2016 Jun 1;6(6):1302-16.eCollection 2016.
    BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma (BMPR2-pSMAD1 / 5信号通路调节RUNX2表达,并影响去分化软骨肉瘤的进展)

  261. Arthritis Rheumatol. 2016 Apr;68(4):953-64.doi: 10.1002/art.39485. (IF:6.009).
    In Vivo Therapeutic Success of MicroRNA‐155 (miR‐155) Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage.(miR‐155拮抗剂体内成功治疗狼疮性肺泡出血模型的小鼠)

  262. Mol Brain. 2016 Apr 23;9:44.doi: 10.1186/s13041-016-0226-2.
    LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia.(长链非编码RNA NONRATT021972 干扰RNA可通过作用于背根神经节P2X7受体调节2型糖尿病大鼠神经性疼痛的行为)

  263. Med Sci Monit. 2016 Apr 7;22:1161-70.doi: 10.12659/msm.897909.
    MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-β1, Smad3, and HDAC4 Signaling.(miR-206通过TGF-β1、Smad3和HDAC4信号调控卫星细胞分化进而减弱大鼠骨骼肌萎缩)

  264. J Cardiovasc Pharmacol Ther. 2016 Mar;21(2):209-18.doi: 10.1177/1074248415599265. Epub 2015 Aug 14.
    Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway.(冠状动脉微栓塞可通过激活lox-1依赖型线粒体通路和半胱天冬酶-8依赖型通路引起猪的心肌细胞凋亡)

  265. Cell Death Dis. 2016 Mar 24;7(3):e2151.doi: 10.1038/cddis.2016.56.
    Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α.(抑制糖原合成酶激酶3β可以促进自噬以保护小鼠免受由过氧化物酶体增殖物激活受体介导的急性肝衰竭的的损害)

  266. J Exp Clin Cancer Res. 2016 Mar 11;35:44.doi: 10.1186/s13046-016-0321-3.
    Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway(PI3K/Akt 信号通路中SOX2基因的抑制可以诱导尤文肉瘤细胞凋亡及G1/S的捕捉)

  267. PLoS One. 2016 Mar 9;11(3):e0149257.doi: 10.1371/journal.pone.0149257. eCollection 2016.
    MiR-3162-3p Is a Novel MicroRNA That Exacerbates Asthma by Regulating β-Catenin.( MiR-3162-3p通过调控β-链蛋白从而加剧哮喘的发作)

  268. Eur J Pharmacol. 2016 Jan 15;771:241-6.doi: 10.1016/j.ejphar.2015.11.051. Epub 2015 Dec 4.
    Effect of vasopressin on Na(+)-K(+)-2Cl(-) cotransporter (NKCC) and the signaling mechanisms on the murine late distal colon.(抗利尿激素对Na(+)-K(+)-2Cl(-) 协同转运蛋白的作用以及对小鼠远端结肠的信号机制)

  269. Cell Mol Life Sci. 2015 Dec;72(24):4849-66.doi: 10.1007/s00018-015-1973-4. Epub 2015 Jun 26. (IF:5.808).
    Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium.(肺微血管内皮细胞)

  270. Endocrinology. 2015 Nov;156(11):4244-56.doi: 10.1210/en.2015-1217. Epub 2015 Sep 11.
    Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.(雷帕霉素靶蛋白不敏感组分(Rictor)通过控制小鼠睾丸支持细胞骨架的组织和细胞极性调节精子发生)

  271. Brain Behav Immun. 2015 Oct;49:75-85.doi: 10.1016/j.bbi.2015.04.014. Epub 2015 Apr 29. (IF:5.889).
    MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation.(MicroRNA let-7c-5p通过抑制小胶质细胞活化防止脑缺血损伤)

  272. Graefes Arch Clin Exp Ophthalmol. 2015 Oct;253(10):1765-76.doi: 10.1007/s00417-015-3067-2. Epub 2015 May 31.
    Effects of CD25siRNAgene transfer on high-risk rat corneal graft rejection.(高危大鼠角膜移植片排斥中CD25siRNA基因转移作用)

  273. Crit Care Med. 2015 Sep;43(9):e369-81.doi: 10.1097/CCM.0000000000001146.
    Cyclophilin A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury After Subarachnoid Hemorrhage in Rats.(大鼠蛛网膜下腔出血早期亲环蛋白A/CD147相互作用) (IF:7.422).

  274. Hepatology. 2015 Sep;62(3):801-15.doi: 10.1002/hep.27887. Epub 2015 Jul 3.
    MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4.((MicroRNA-125b通过small mothers减少Dpp2和4以减弱上皮细胞-间充质细胞转化并作用于肝癌细胞干细胞)(IF:11.711).

  275. Endocrine. 2015 Aug;49(3):752-60.doi: 10.1007/s12020-015-0546-5. Epub 2015 Feb 11.
    MiR-346 regulates CD4+CXCR5 + T cells in the pathogenesis of Graves’ disease.(甲状腺)

  276. Oncotarget. 2015 Apr 20;6(11):8900-13.doi: 10.18632/oncotarget.3561.
    Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.(巨噬细胞通过在仿生气道芯片培养和动物模型的κB和STAT3信号通路的活化从而促进苯并芘诱导的人支气管上皮细胞肿瘤的转化)(IF:5.168).

  277. Basic Res Cardiol. 2015 May;110(3):28.doi: 10.1007/s00395-015-0484-7. Epub 2015 Apr 10. (IF:6.038).
    Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction.(Sialyltransferase7A,一个Klf4的应答基因,在心肌梗死中促进心肌细胞凋亡)

  278. PLoS One. 2015 Mar 20;10(3):e0120046.doi: 10.1371/journal.pone.0120046. eCollection 2015.
    ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression.(ENTPD5通过调控Caspase 3表达诱导肺癌细胞凋亡)

  279. Cancer Res. 2015 Mar 15;75(6):1080-90.doi: 10.1158/0008-5472.CAN-14-1831. Epub 2015 Jan 19. (IF:9.329).
    Targeting LunX inhibits non-small-cell lung cancer growth and metastasis.(肺癌)

  280. Exp Biol Med (Maywood). 2015 Nov;240(11):1426-33.doi: 10.1177/1535370215573400. Epub 2015 Mar 13.
    Mechanism of programmed cell death factor 4/nuclear factor-κB signaling pathway in porcine coronary micro-embolization-induced cardiac dysfunction.细胞死亡因子4/NF-κB在猪冠状动脉微栓塞引起的心脏功能障碍中的发生机制)

  281. J Neuroinflammation. 2015 Jan 28;12:18.doi: 10.1186/s12974-014-0233-0. (IF:5.408).
    NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.NLRP1(炎性体在内侧颞叶癫痫患者中被激活并能促进在杏仁核刺激的大鼠模型的神经元细胞死亡)

  282. Cell Death Dis. 2014 Dec 11;5(12):e1571.doi: 10.1038/cddis.2014.540. (IF:5.014).
    BMPR2 inhibition induced apoptosis and autophagy via destabilization of XIAP in human chondrosarcoma cells.(软骨肉瘤相关,siRNA皮下肿瘤注射)

  283. Mol Cancer. 2014 Sep 6;13:206.doi: 10.1186/1476-4598-13-206. (IF:5.683).
    Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.(肿瘤相关研究)

  284. Cell Death Dis. 2014 Aug 21;5(8):e1382.doi: 10.1038/cddis.2014.348.
    Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease.(阿尔茨海默病)(IF:5.014).

  285. J Alzheimers Dis. 2014;38(3):633-46.doi: 10.3233/JAD-131148.
    IL12/23 p40 Inhibition Ameliorates Alzheimer’s Disease-Associated Neuropathology and Spatial Memory in SAMP8 Mice.(脑室注射siRNA研究对阿耳茨海默氏病的治疗)

  286. Mol Immunol. 2014 May;59(1):30-8.doi: 10.1016/j.molimm.2013.12.004. Epub 2014 Jan 22.
    Inhibition of IL-2 inducible T-cell kinase alleviates T-cell activation and murine myocardial inflammation associated with CVB3 infection.(心脏疾病)

  287. Neurosci Lett. 2014 Apr 30;566:298-303.doi: 10.1016/j.neulet.2014.02.066. Epub 2014 Mar 12.
    Autophagic effect of programmed cell death 5 (PDCD5) after focal cerebral ischemic reperfusion injury in rats.(凋亡相关研究)

  288. Biomed Res Int. 2014;2014:898646.doi: 10.1155/2014/898646. Epub 2014 Jun 26.
    Trichinella spiralis excretory-secretory products protect against polymicrobial sepsis by suppressing MyD88 via mannose receptor.(免疫系统)

  289. J Neuroimmunol. 2014 Jan 15;266(1-2):56-63.doi: 10.1016/j.jneuroim.2013.09.019. Epub 2013 Oct 8.
    MicroRNA-155 Modulates Th1 and Th17 Cell Differentiation and is Associated with Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.(注射miRNA研究对免疫疾病的作用机理)

  290. J Neuroimmunol. 2014 Jan 15;266(1-2):56-63.doi: 10.1016/j.jneuroim.2013.09.019. Epub 2013 Oct 8.
    MicroRNA-155 Modulates Th1 and Th17 Cell Differentiation and is Associated with Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.(注射miRNA研究对免疫疾病的作用机理)

  291. J Biol Chem. 2013 Nov 29;288(48):34612-26.doi: 10.1074/jbc.M113.494369. Epub 2013 Oct 4.
    Heme Oxygenase-1 Exerts a Protective Role in Ovalbumin-induced Neutrophilic Airway Inflammation by Inhibiting Response in the Immune Cells Th17.(肺过敏性哮喘)

  292. Int J Nanomedicine . 2013;8:3805-16. doi: 10.2147/IJN.S48950. Epub 2013 Oct 2. Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-α and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line. (IF:6.400).

  293. Purinergic Signal. 2013 Sep;9(3):463-79.doi: 10.1007/s11302-013-9367-2. Epub 2013 Jun 11.
    Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor.(舌下静脉注射siRNA干扰脊神经背根神经节受体)

  294. CNS Neurosci Ther. 2013 Aug;19(8):566-76.doi: 10.1111/cns.12114. Epub 2013 May 3.
    The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.(脑室注射siRNA研究脑缺血的凋亡机理)

  295. Curr Pharm Des. 2013;19(7):1242-52.doi: 10.2174/138161213804805739.
    MicroRNAs (miRNAs) in colorectal cancer: From aberrant expression towards therapy.

  296. Matrix Biol. 2013 Jun 24;32(5):265-76.doi: 10.1016/j.matbio.2013.02.004. Epub 2013 Mar 5. (IF:5.074).
    Transdermal siRNA-TGFβ1-337 patch for hypertrophic scar treatment.(皮肤涂抹siRNA研究治疗皮肤瘢痕)

  297. J Cereb Blood Flow Metab. 2013 Mar;33(3):396-406.doi: 10.1038/jcbfm.2012.179. Epub 2013 Jan 9. (IF:5.407).
    SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. (脑室注射siRNA研究脑缺血机理)

  298. Cancer Lett. 2012 Jan 28;314(2):223-31.doi: 10.1016/j.canlet.2011.09.033. Epub 2011 Oct 5. (IF:5.621).
    Epub 2011 Oct 5.NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA.(皮下肿瘤注射miRNA研究治疗结肠癌)

  299. Progress in Modern Biomedicine. 2010 Sep.
    Anti-Virus Research on Short Double-Stranded RNA in Mouse Models with Viral Myocarditis.

应用本产品文献

发表的部分文献分器官导读

在线查看文章:https://files.engreen.info/share/detail/8fbe069f-6e6f-4937-7461-b2e1519bf000 提取码:btv9

序号 研究方向 实验材料 文章题目 期刊
大脑
1 大脑皮层 miRNA mimic and inhibitor Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury Experimental Neurology
2 大脑(阿尔兹

海默症)

miRNA MicroRNA-23b attenuates tau pathology and inhibits oxidative stress by targeting GnT-III in Alzheimer’s disease Neuropharmacology
3 大脑海马 shRNA Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice Journal of Neuroinflammation
4 大脑海马 siRNA Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats Cell Cycle
5 血脑屏障 siRNA Semaphorin 3A Contributes to Secondary Blood–Brain Barrier Damage After Traumatic Brain Injury Frontiers in Cellular Neuroscience
6 脑缺血损伤 agomiRNA miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN Molecular Medicine REPORTS
7 脑缺血损伤 miRNA agomir Inhibition of miR-200b-3p alleviates hypoxia-ischemic brain damage via targeting Slit2 in neonatal rats Biochemical and Biophysical Research Communications
8 脑损伤 miRNA inhibitor The role of microRNA-146a in regulating the expression of

IRAK1 in cerebral ischemia-reperfusion injury

Canadian Journal of Physiology and Pharmacology
9 脑水肿 dsRNA Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat model EXPERIMENTAL AND THERAPEUTIC MEDICINE
10 大脑神经 siRNA Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate is chemic neuronal death by targeting miR-21/PDCD4 signaling pathway Cell Death and Disease
11 大脑神经 miRNA miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway AGING
神经
1 背根神经 shRNA Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor Frontiers in Psychiatry
2 周围神经 siRNA Suppressing BRD4 exhibits protective effects against vincristineinduced peripheral neuropathy by alleviating inflammation and oxidative stress Biochemical and Biophysical Research Communications
脊髓
1 自身免疫性脑脊髓炎 miRNA miR‑20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis Journal of Translational Medicine
2 创伤性

脊髓损伤

siRNA MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/MDM-2/p53 pathway after traumatic spinal cord injury in rats BioFactors
眼睛
1 角膜 siRNA CD25 siRNA induces Treg/Th1 cytokine expression in rat corneal transplantation models Experimental Eye Research
2 视网膜 miRNA mimic Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2 Cellular Signalling
1 鼻炎 miRNA mimic MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway Open Medicine
口腔
1 口腔鳞状

细胞癌

siRNA OSCC cell‑secreted exosomal CMTM6 induced M2‑like macrophages polarization via ERK1/2 signaling pathway Cancer Immunology, Immunotherapy
心脏
1 心力衰竭 miRNA Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation AGING
2 心肌缺血 miRNA MiR-23a Is Involved in Myocardial Ischemia/ Reperfusion Injury by Directly Targeting CX43 and Regulating Mitophagy Inflammation
3 心肌损伤 siRNA Role of high‐mobility group B1 in myocardial injury induced by coronary microembolization in rats J Cell Biochem
4 病毒性心肌炎 shRNA Short hairpin RNA targeting 2B gene of coxsackievirus B3 exhibits potential antiviral effects both in vitro and in vivo BMC Infectious Diseases
支气管
1 支气管

(哮喘)

miRNA Divergent Roles of miR-3162-3p in Pulmonary Inflammation in Normal and Asthmatic Mice as well as Antagonism of miR-3162-3p in Asthma Treatment Int Arch Allergy Immunol
2 支气管

(哮喘)

miRNA Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model Cell and Tissue Research
肺部
1 肺纤维化 pAAV-FTS1-GFP-miRNA Transforming growth factor (TGF)-β1-induced

miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

Cell Death and Disease
2 肺泡出血 miRNA antagomir In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage ARTHRITIS & RHEUMATOLOGY
3 肺癌 miRNA ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression PLOS ONE
4 肺损伤 siRNA LPS-induced vein endothelial cell injury and acute lung injury have Btk and

Orai 1 to regulate SOC-mediated calcium influx

International Immunopharmacology
5 急性肺损伤 siRNA CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-κB signaling Biomedicine & Pharmacotherapy
6 肺动脉高压 shRNA LncRNA Tug1 involves in the pulmonary vascular remodeling

in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1

Life Sciences
1 胃癌 siRNA CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer Theranostics
2 胃酸分泌 siRNA Source of dopamine in gastric juice and luminal dopamine induced duodenal bicarbonate secretion via apical dopamine D2 receptors The British Pharmacological Society
胰腺
1 胰腺

(糖尿病)

circRNA Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1diabetes mellitus Theranostics
肝脏
1 肝脏炎症 miRNA agomir Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation International Immunopharmacology
2 肝损伤 siRNA Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by upregulating the FGF21/PGC-1α pathway The British Pharmacological Society
3 乙型肝炎 siRNA Hepatitis B Virus Can Be Inhibited by DNA Methyltransferase 3a via Specific Zinc-Finger-Induced Methylation of the X Promoter BIOCHEMISTRY
4 肝 (糖异生) siRNA Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction Nature Communications
5 肝癌 siRNA MicroRNA-125b Attenuates Epithelial-Mesenchymal Transitions and Targets Stem-Like Liver Cancer Cells Through Small Mothers Against Decapentaplegic 2 and 4 HEPATOLOGY
6 急性肝衰竭 RNA mimics Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on the autophagy pathway Molecular Medicine REPORTS
7 非酒精性

脂肪肝

siRNA Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress Free Radical Biology and Medicine
1 结直肠 miRNA mimic Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer Cancer Letters
2 结直肠 siRNA Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer Journal of Experimental & Clinical Cancer Research
3 结肠 siRNA Effect of vasopressin on Na+–K+–2Clcotransporter(NKCC)and the signaling mechanisms on the murine late distal colon European Journal of Pharmacology
4 肠道 siRNA Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway Redox Biology
1 软骨肉瘤 siRNA BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma Am J Cancer Res
2 骨形成 miRNA miR-129-5p Inhibits Bone Formation Through TCF4 Frontiers in Cell and Developmental Biology
3 骨质疏松 shRNA Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats Bioscience Reports
4 骨坏死 siRNA TET3 mediates alterations in the epigenetic marker 5hmC and Akt pathwayin steroid-associated osteonecrosis† Journal of Bone and Mineral Research
5 骨关节炎 miRNA mimic Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis GENETIC TESTING AND MOLECULAR BIOMARKERS
肌肉
1 肌肉增殖 circRNA CircRILPL1 promotes muscle proliferation and differentiation via binding miR-145 to activate IGF1R/PI3K/AKT pathway Cell Death & Disease
2 骨骼肌萎缩 miRNA MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-b1, Smad3, and HDAC4 Signaling Med Sci Monit
3 肌肉生成 siRNA HMGB2 Regulates Satellite Cell-Mediated Skeletal Muscle Regeneration via IGF2BP2 Journal of Cell Science
肾脏
1 肾纤维化 miRNA Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction Stem Cell Research & Therapy
2 肾细胞癌 siRNA Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539 Cell Cycle
3 肾炎 miRNA agomir MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells Arthritis & Rheumatology
4 肾损伤 miRNA miR-211 alleviates ischaemia/reperfusion-induced kidney injury by targeting TGFβR2/TGF-β/SMAD3 pathway Bioengineered
膀胱
1 膀胱癌 siRNA Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models Investigational New Drugs
乳腺
1 乳腺癌 miRNA inhibitor ZLM‑7 inhibits the occurrence and angiogenesis of breast cancer through miR‑212‑3p/Sp1/VEGFA signal Molecular Medicine
2 乳腺癌 shRNA Short hairpin RNA targeting 2B gene of coxsackievirus B3 exhibits potential antiviral effects both in vitro and in vivo BMC Infectious Diseases
生殖系统
1 卵巢癌 shRNA LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1 Cancer Gene Therapy
2 睾丸生殖

细胞肿瘤

miRNA antagomir A miR-125b/CSF1-CX3CL1/tumorassociated macrophage recruitment axis controls testicular germ cell tumor growth Cell Death and Disease
腹膜
1 腹膜纤维化 miRNA inhibitor Long noncoding RNA AK089579 inhibits epithelial-to-mesenchymal transition of peritoneal mesothelial cells by competitively binding to microRNA-296-3p via DOK2 in peritoneal fibrosis The FASEB Journal
免疫系统
1 红斑狼疮 miRNA LncRNA MIAT enhances systemic lupus erythematosus by upregulating CFHR5 expression via miR-222 degradation Experimental immunology
2 肥大细胞

荨麻疹

siRNA SELE Downregulation Suppresses Mast Cell Accumulation to Protect against Inflammatory Response in Chronic Idiopathic Urticaria Int Arch Allergy Immunol
3 自身免疫性

脑脊髓炎

miRNA miR‑20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis Journal of Translational Medicine
皮肤
1 疤痕 miRNA miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of TGF-β1/Smad/CTGF signaling pathway Canadian Journal of Physiology and Pharmacology
其他动物
1 七鳃鳗 miRNA mimics, inhibitor MicroRNA expression profile in Lampetra morii upon Vibrio anguillarum infection and miR-4561 characterization targeting lip COMMUNICATIONS BIOLOGY
2 海参 dsRNA Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus Frontiers in Genetics
3 鸡胚 siRNA lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway Molecular Therapy: Nucleic Acids
4 飞蝗 miRNA The microRNAs let-7 and miR-278 regulate insect metamorphosis and oogenesis by targeting the juvenile hormone early-response gene Krüppel-homolog 1 The Company of Biologists Ltd
5 幼蟹 siRNA Molecular characteristics and abundance of insulin-like androgenic gland

hormone and effects of RNA interference in Eriocheir sinensis

Animal Reproduction Science
6 半滑舌鳎鱼 siRNA Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossussemilaevis) spleen identifies cellular processes essential to viral infection Developmental and Comparative Immunology
7 siRNA Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway Journal of Cardiovascular

Pharmacology and Therapeutics

产品说明书

点此去下载

  1. EntransterTM系列转染试剂的成分和原理,化学结构,粒径,电位等数据

  2. siRNA转染后什么时候做qRT-PCR最好? siRNA转染后什么时候做蛋白检测检测最好?

  3. siRNA转染与DNA转染有什么不一样?

  4. 体内转染常见问题

  5. 体内转染和病毒感染的比较

  6. 转基因动物/基因敲除动物与体内转染的比较

  7. 小鼠尾静脉注射技巧

相关问题

运输与储存

常温运输,储存于4℃。

质量保证

北京英格恩生物科技有限公司本产品实行严格质量检验,并进行转染验证,以确保产品质量。请用户使用前务必认真阅读操作手册。如用户仍然有问题,请立即联系本公司人员,英格恩公司将负责提供全程技术服务。

使用限制

本品仅限科研用途。

联系我们

在线客服
在线客服
热线电话
关注微信/技术支持
0